Table 2. Frequency distribution of BCP and PC mutations among study groups, HBeAg status and HBV genotypes.
| Mutations | Study groups, n(%) | P-value | HBeAg status, n (%) |
P-value |
Genotypes, n (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIV co-infected (n = 48) | Blood donors (n = 43) | CLD patients (n = 52) | Total (n = 143) | Positive (n = 54) |
Negative (n = 89) |
Total (n = 143) | A(n = 86) | D(n = 56) | E(n = 1) | Total | P-value* | ||||
| BCP mutations | C1674T | 22(45.8) | 13(30.2) | 17(32.7) | 52(36.4) | 0.24 | 14(25.9) | 38(42.7) | 52(36.4) | 0.07 | 3(3.5) | 48(85.7) | 1(100) | 52(36.4) | <0.001 |
| A1676T | 18(37.5) | 13(27.9) | 17(32.7) | 47(32.9) | 0.62 | 12(22.2) | 35(39.3) | 47(32.9) | 0.05 | 3(3.5) | 43(76.8) | 1(100) | 47(32.9) | <0.001 | |
| C1678T/A | 19(39.6) | 11(25.6) | 17(32.7) | 47(32.9) | 0.37 | 12(22.2) | 35(39.3) | 47(32.9) | 0.05 | 3(3.5) | 44(78.6) | 0(0.0) | 47(32.9) | <0.001 | |
| C1703A | 20(41.7) | 12(27.9) | 17(32.7) | 49(34.3) | 0.37 | 15(27.8) | 34(38.2) | 49(34.3) | 0.28 | 9(10.5) | 39(69.6) | 1(100) | 49(34.3) | <0.001 | |
| G1719T | 23(47.9) | 17(39.5) | 18(34.6) | 58(40.6) | 0.40 | 15(27.8) | 43(48.3) | 58(40.6) | 0.03 | 4(4.7) | 53(94.6) | 1(100) | 58(40.6) | <0.001 | |
| A1727G | 6(12.5) | 5(11.6) | 1(1.9) | 12(8.4) | 0.11 | 8(9.0) | 4(7.4) | 12(8.4) | 0.74 | 3(3.5) | 9(16.1) | 0(0.0) | 12(8.4) | 0.03 | |
| C1730 | 1(2.1) | 1(2.3) | 1(1.9) | 3(2.1) | 0.99 | 2(3.7) | 1(1.1) | 3(2.1) | 0.66 | 1(1.2) | 2(3.6) | 0(0.0) | 3(2.1) | 0.61 | |
| T1741C | 1(2.1) | 0(0.0) | 3(1.9) | 4(2.8) | 0.22 | 2(3.7) | 2(2.2) | 4(2.8) | 0.63 | 2(2.4) | 2(3.6) | 0(0.0) | 4(2.8) | 0.87 | |
| A1752C/G/T | 6(12.5) | 4(9.3) | 2(3.8) | 12(8.4) | 0.29 | 2(3.7) | 10(11.2) | 12(8.4) | 0.13 | 3(3.5) | 9(16.1) | 0(0.0) | 12(8.4) | 0.03 | |
| T1753V* | 7(14.6) | 10(23.3) | 10(19.2) | 27(18.9) | 0.57 | 3(5.6) | 24(27) | 27(18.9) | <0.001 | 7(8.1) | 20(35.7) | 0(0.0) | 27(18.9) | <0.001 | |
| G1757A | 20(41.7) | 11(25.6) | 18(34.6) | 49(34.3) | 0.31 | 13(24.1) | 36(40.4) | 49(34.3) | 0.07 | 3(3.5) | 45(80.4) | 1(100) | 49(34.3) | <0.001 | |
| T1758C | 0(0.0) | 0(0.0) | 1(1.9) | 1(0.7) | 0.41 | 0(0.0) | 1(1.1) | 1(0.7) | 0.99 | 0(0.0) | 1(1.8) | 0(0.0) | 1(0.7) | 0.46 | |
| A1760C | 0(0.0) | 1(2.3) | 0(0.0) | 1(0.7) | 0.31 | 0(0.0) | 1(1.1) | 1(0.7) | 0.99 | 1(1.2) | 0(0.0) | 0(0.0) | 1(0.7) | 0.71 | |
| A1761C | 2(4.2) | 1(2.3) | 0(0.0) | 3(2.1) | 0.35 | 0(0.0) | 3(3.4) | 3(2.1) | 0.29 | 1(1.2) | 2(3.6) | 0(0.0) | 3(2.1) | 0.61 | |
| A1762T | 4(8.3) | 16(37.3) | 21(40.4) | 41(28.7) | 0.001 | 15(27.8) | 26(29.2) | 41(28.7) | 0.99 | 33(38.4) | 8(14.3) | 0(0.0) | 41(28.7) | 0.01 | |
| G1763A | 0(0.0) | 1(2.3) | 2(3.8) | 3(2.1) | 0.40 | 0(0.0) | 3(3.4) | 3(2.1) | 0.29 | 1(1.2) | 2(3.6) | 0(0.0) | 3(2.1) | 0.61 | |
| G1764A | 6(12.5) | 19(44.2) | 25(48.1) | 50(35.0) | <0.001 | 21(38.9) | 29(32.6) | 50(35.0) | 0.56 | 38(44.2) | 12(21.4) | 0(0.0) | 50(35.0) | 0.02 | |
| C1766T | 5(10.4) | 4(9.3) | 12(23.1) | 21(14.7) | 0.10 | 10(18.5) | 11(12.4) | 21(14.7) | 0.44 | 17(19.8) | 4(7.1) | 0(0.0) | 21(14.7) | 0.06 | |
| T1767A | 1(2.1) | 1(2.3) | 0(0.0) | 2(1.4) | 0.56 | 1(1.9) | 1(1.1) | 2(1.4) | 0.99 | 2(2.4) | 0(0.0) | 0(0.0) | 2(1.4) | 0.50 | |
| T1768A | 3(6.2) | 0(0.0) | 10(19.2) | 13(9.1) | 0.004 | 7(13) | 6(6.7) | 13(9.1) | 0.34 | 8(9.3) | 5(8.9) | 0(0.0) | 13(9.1) | 0.90 | |
| T1771C | 0(0.0) | 0(0.0) | 1(1.9) | 1(0.7) | 0.41 | 1(1.9) | 0(0.0) | 1(0.7) | 0.99 | 0(0.0) | 1(1.8) | 0(0.0) | 1(0.7) | 0.46 | |
| A1772C | 1(0.7) | 0(0.0) | 0(0.0) | 1(0.7) | 0.37 | 0(0.0) | 1(1.1) | 1(0.7) | 0.99 | 0(0.0) | 1(1.8) | 0(0.0) | 1(0.7) | 0.46 | |
| T1773C | 22(45.8) | 14(32.6) | 17(32.7) | 53(37.1) | 0.30 | 14(25.9) | 39(43.8) | 53(37.1) | 0.03 | 3(3.5) | 49(87.5) | 1(100) | 53(37.1) | <0.001 | |
| G1775A | 0(0.0) | 1(2.3) | 0(0.0) | 1(0.7) | 0.31 | 1(1.9) | 0(0.0) | 1(0.7) | 0.38 | 0(0.0) | 1(1.8) | 0(0.0) | 1(0.7) | 0.46 | |
| C1799T | 0(0.0) | 0(0.0) | 1(1.9) | 1(0.7) | 0.41 | 0(0.0) | 1(1.1) | 1(0.7) | 0.99 | 0(0.0) | 1(1.8) | 0(0.0) | 1(0.7) | 0.46 | |
| T1809G | 21(43.8) | 10(23.3) | 16(30.8) | 47(32.9) | 0.11 | 13(24.1) | 34(38.2) | 47(32.9) | 0.12 | 2(2.3) | 44(78.6) | 1100) | 47(32.9) | <0.001 | |
| C1810A/T | 0(0.0) | 2(4.7) | 2(3.8) | 4(2.8) | 0.34 | 2 (3.7) | 2(2.2) | 4(2.8) | 0.63 | 4(4.7) | 0(0.0) | 0(0.0) | 4(2.8) | 0.25 | |
| A1811C | 4(8.3) | 7(16.3) | 3(5.8) | 14(9.8) | 0.21 | 2(3.7) | 12(13.5) | 14(9.8) | 0.08 | 12(14.0) | 2(3.6) | 0(0.0) | 14(9.8) | 0.11 | |
| T1812C | 22(45.8) | 12(27.9) | 21(40.4) | 55(38.5) | 0.20 | 16(29.6) | 39(43.8) | 55(38.5) | 0.13 | 6(7.0) | 48(85.7) | 1(100) | 55(38.5) | <0.001 | |
| PC mutations | A1814C | 7(14.6) | 7(16.3) | 8(15.4) | 22(15.4) | 0.98 | 3(5.6) | 19(21.3) | 22(15.4) | 0.02 | 15(17.4) | 7(12.5) | 0(0.0) | 22(15.4) | 0.59 |
| C1816T | 1(2.1) | 1(2.3) | 0(0.0) | 2(1.4) | 0.56 | 0(0.0) | 2(2.2) | 2(1.4) | 0.53 | 0(0.0) | 2(3.6) | 0(0.0) | 2(1.4) | 0.21 | |
| C1845G/T | 0(0.0) | 0(0.0) | 1(1.9) | 1(0.7) | 0.41 | 1(1.9) | 0(0.0) | 1(0.7) | 0.38 | 1(1.2) | 0(0.0) | 0(0.0) | 1(0.7) | 0.71 | |
| A1850T | 22(45.8) | 9(20.9) | 15(28.8) | 46(32.2) | 0.03 | 13(24.1) | 33(37.1) | 46(32.2) | 0.15 | 10(11.6) | 35(62.5) | 1(100) | 46(32.2) | <0.001 | |
| C1858T | 23(47.9) | 14(32.6) | 21(40.4) | 58(40.6) | 0.33 | 16(29.6) | 42(47.2) | 58(40.6) | 0.06 | 9(10.5) | 48(85.7) | 1(100) | 58(40.6) | <0.001 | |
| G1862T | 22(45.8) | 21(48.8) | 21(40.4) | 64(44.8) | 0.70 | 20(37.0) | 44(49.4) | 64(44.8) | 0.20 | 29(32.9) | 34(60.7) | 1(100) | 64(44.8) | <0.001 | |
| G1888A/T | 14(29.2) | 12(27.9) | 17(32.7) | 43(30.1) | 0.87 | 24(44.4) | 19(21.3) | 43(30.1) | 0.01 | 39(45.3) | 4(7.1) | 0(0.0) | 43(30.1) | <0.001 | |
| G1896A | 9(18.8) | 14(32.6) | 13(25) | 36(25.2) | 0.32 | 4(7.4) | 32(36.0) | 36(25.2) | <0.001 | 5(5.8) | 31(55.4) | 0(0.0) | 36(25.2) | <0.001 | |
| G1899A | 9(18.8) | 9(20.9) | 10(19.2) | 28(19.6) | 0.96 | 6(11.1) | 22(24.7) | 28(19.6) | 0.08 | 10(11.6) | 18(32.1) | 0(0.0) | 28(19.6) | 0.004 | |
*V-stands for A or C or G.