Fig 10. Neutralization of JRFL WT and mutant viruses by different MAbs and CD4-IgG2.

Neutralization assays were performed for each of MAb-virus pairs as described in Fig 2. AUC values were calculated from titration curves. A) Titration curves of representative virus-MAb pairs. B) JRFL WT and mutant neutralization by MAbs targeting V2i, V3, V2q, and the CD4bs and by CD-IgG2. AUC values that decreased by >30% and had p<0.05 relative to WT are shown in red. Means and standard errors from two to three experiments are shown.