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. 2018 Feb 6;13(2):e0192319. doi: 10.1371/journal.pone.0192319

Table 3. Clinical therapeutic efficacy, M-TXYF vs. RP.

Study Effective rate, % (efficacy/N) Therapeutic gain, % NNT OR (95% CI)
M-TXYF Positive medicine
An et al. 2017 (10) 96.9 (31/32) 75.0 (24/32) 21.9 4.6 10.33 (1.21, 88.36)
Chen et al. 2016 (11) 93.3 (28/30) 70.0 (21/30) 23.3 4.3 6.00 (1.17, 30.72)
Ge et al. 2016 (12) 93.5 (58/62) 71.0 (44/62) 22.5 4.4 5.93 (1.87, 18.77)
Ma et al. 2016 (13) 91.3 (21/23) 69.6 (16/23) 21.7 4.6 4.59 (0.84, 25.16)
Qian et al. 2016 (14) 96.7 (29/30) 76.7 (23/30) 20.0 5.0 8.83 (1.01, 76.96)
Li et al. 2015 (15) 90.0 (27/30) 73.3 (22/30) 16.7 6.0 3.27 (0.77, 13.83)
Li 2015 (16) 90.5 (38/42) 71.4 (30/42) 19.1 5.2 3.80 (1.11, 12.98)
Peng et al. 2014 (17) 88.9 (24/27) 65.2 (15/23) 23.7 4.2 4.27 (0.98, 18.66)
Wen et al. 2014 (18) 92.9 (39/42) 73.8 (31/42) 19.1 5.2 4.61 (1.18, 17.99)
Chen et al. 2014 (19) 82.8 (48/58) 77.6 (35/58) 5.2 19.2 3.15 (1.33, 7.46)
Zhang et al. 2014 (20) 90.7 (39/43) 69.0 (29/42) 21.7 4.6 5.98 (1.56, 22.90)
Tu 2013 (21) 96.4 (54/56) 93.8 (45/48) 2.6 38.5 1.80 (0.29, 11.25)
Wang et al. 2013 (22) 89.5 (43/48) 76.0 (38/50) 13.5 7.4 2.72 (0.88, 8.41)
Wang et al. 2012 (23) 93.3 (42/45) 75.6 (34/45) 17.7 5.6 4.53 (1.17, 17.55)
Tao et al. 2012 (24) 94.1 (64/68) 79.7 (51/64) 14.4 6.9 4.08 (1.25, 13.27)
Xu et al. 2011 (25) 98.1 (51/52) 79.0 (41/52) 19.1 5.2 13.68 (1.70, 110.40)
Zhang 2010 (26) 93.0 (37/40) 63.0 (25/40) 30.0 3.3 7.40 (1.94, 28.24)
Zhang et al. 2009 (27) 90.6 (48/53) 70.4 (38/54) 20.2 5.0 4.04 (1.36, 12.03)
Liang et al. 2009 (28) 85.0 (17/20) 45.0 (9/20) 40.0 2.5 6.93 (1.53, 31.38)
Pan et al. 2009 (29) 90.9 (70/77) 92.5 (37/40) -1.6 -62.5 0.81 (0.20, 3.32)
Gao et al. 2009 (30) 71.6 (53/74) 40.9 (9/22) 30.7 3.3 3.65 (1.36, 9.80)
Fang 2008 (31) 90.0 (36/40) 70.0 (28/40) 20.0 5.0 3.86 (1.12, 13.26)
Cai et al. 2006 (32) 86.7 (52/60) 77.4 (24/31) 9.3 10.8 1.90 (0.62, 5.83)
Pooled OR 90.3 (950/1052) 72.7 (669/920) 17.6 5.7 4.04 (3.09, 5.27)

NNT, number needed to treat; OR, odds ratio.