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. 2018 Feb 6;13(2):e0192243. doi: 10.1371/journal.pone.0192243

Table 3. Subgroup analysis.

Outcomes Group OR and 95%CI P value Heterogeneity (%) P value for heterogeneity P value for heterogeneity between subgroups
30-day survival rate Publication year
2005 or after 1.48(0.78–2.78) 0.228 0.0 0.798 0.674
Before 2005 1.91(0.70–5.22) 0.210 0.0 0.905
Study design
Prospective 1.86(0.87–3.96) 0.108 0.0 0.723 0.562
Retrospective 1.35(0.63–2.89) 0.436 0.0 0.947
Sample size
100 or larger 2.06(0.89–4.77) 0.090 0.0 0.767 0.424
< 100 1.32(0.66–2.65) 0.433 0.0 0.947
Mean age (years)
60 or older 1.43(0.78–2.61) 0.250 0.0 0.878 0.456
< 60 2.34(0.74–7.46) 0.149 0.0 0.972
Percentage male (%)
50 or larger 1.55(0.86–2.81) 0.147 0.0 0.933 0.877
<50 1.74(0.51–5.99) 0.378 0.0 0.469
10-month survival rate Publication year
2005 or after 1.22(0.77–1.93) 0.398 14.4 0.322 1.000
Before 2005 1.06(0.25–4.54) 0.938 74.3 0.009
Study design
Prospective 1.17(0.77–1.79) 0.457 10.6 0.340 1.000
Retrospective 1.28(0.34–4.81) 0.717 68.3 0.013
Sample size
100 or larger 1.32(0.85–2.05) 0.217 0.0 0.859 1.000
< 100 1.18(0.53–2.65) 0.685 62.4 0.014
Mean age (years)
60 or older 0.96(0.45–2.05) 0.919 56.2 0.044 0.256
< 60 1.91(0.80–4.59) 0.147 34.8 0.216
Percentage male (%)
50 or larger 1.13(0.58–2.22) 0.721 56.6 0.032 0.577
<50 1.69(0.52–5.52) 0.386 38.5 0.202
20-month survival rate Publication year
2005 or after 1.74(0.95–3.18) 0.074 0.0 0.562 0.492
Before 2005 2.49(1.09–5.68) 0.031 0.0 0.381
Study design
Prospective 1.81(0.53–6.18) 0.344 48.3 0.145 0.929
Retrospective 1.94(1.07–3.50) 0.028 0.0 0.902
Sample size
100 or larger 1.71(0.76–3.87) 0.194 - - 0.677
< 100 2.13(1.16–3.92) 0.015 0.0 0.510
Mean age (years)
60 or older 1.74(0.95–3.18) 0.074 0.0 0.562 0.492
< 60 2.49(1.09–5.68) 0.031 0.0 0.381
Percentage male (%)
50 or larger 1.93(1.12–3.31) 0.018 0.0 0.422 0.859
<50 2.16(0.71–6.58) 0.177 0.0 0.465
30-month survival rate Publication year
2005 or after 1.33(0.76–2.32) 0.321 0.0 0.835 0.765
Before 2005 1.10(0.36–3.36) 0.872 0.0 0.861
Study design
Prospective 1.12(0.32–3.89) 0.858 0.0 0.875 0.822
Retrospective 1.31(0.76–2.26) 0.333 0.0 0.824
Sample size
100 or larger 1.23(0.65–2.35) 0.523 - - 0.870
< 100 1.34(0.61–2.97) 0.463 0.0 0.917
Mean age (years)
60 or older 1.33(0.76–2.32) 0.321 0.0 0.835 0.765
< 60 1.10(0.36–3.36) 0.872 0.0 0.861
Percentage male (%)
50 or larger 1.22(0.71–2.08) 0.474 0.0 0.971 0.635
<50 1.73(0.45–6.70) 0.426 0.0 0.473

*OR, odds ratio; CI, confidence interval