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. 2018 Feb 6;13(2):e0192286. doi: 10.1371/journal.pone.0192286

Fig 3. Testing LSL-TPP1 in mice.

Fig 3

Where indicated, the stop element was constitutively removed from TgLSL-TPP1 mice by crossing with female animals containing the Zp3-cre transgene. A. Survival of animals expressing TgLSL-TPP1 before cre-mediated recombination (n = 56) or after (TgL-TPP1) (n = 28). Tpp1-/- (n = 1560) and Tpp1+/+ (n = 394) animals without transgene are historical controls. The ratio of median survival for animals with TgLSL-TPP1 (115 days) or controls without the transgene (132 days) was 0.8712 (95% CI 0.4716 to 1.61). B. Brain TPP1 activity in wild-type animals containing TgL-TPP1 (n = 3 animals per genotype). P value for significance between TPP1 activity in animals with or without transgene calculated using an unpaired two-tailed t-test was 0.0001. C. Survival of animals expressing TgL-TPP1 or littermates lacking the transgene in a Tpp1+/+ or Tpp1+/- background. Note that median survivals were undefined.