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. 2018 Feb 6;13(2):e0192286. doi: 10.1371/journal.pone.0192286

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© 2018 Nemtsova et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — Note that animals were not treated with tamoxifen. Median survival and median survival ratio compared to Tpp1^-/- littermate controls for each strain was: Tpp1^-/- littermate controls (n = 161, 60 deaths), median survival 124 days; Tpp1^-/- Tg^UBC-cre/ERT2 (n = 57, 14 deaths), median survival is 579 days, ratio to Tpp1^-/- is 4.825 (95% CI 2.697 to 8.633); Tpp1^-/- Tg^{GFAP-cre/ERT2} (n = 54, 46 deaths), median survival is 117 days, ratio to Tpp1^-/- is 0.975 (95% CI 0.664 to1.432); Tpp1^-/- Tg^{Thy1-cre/ERT2} (n = 19, 4 deaths), median survival is 288 days, ratio to Tpp1^-/- is 2.4 (95% CI 0.8723 to 6.604); Tpp1^-/- Tg^icre/ERT2 (n = 20, 19 deaths), median survival is 99 days, ratio to Tpp1^-/- is 0.8208 (95% CI 0.49 to 1.375); Tpp^f/f (n = 754, 50 deaths), median survival is 639 days, ratio to Tpp1^-/- is 5.325 (95% CI 3.659 to7.75).