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Effects of Prodrug 3 on MMP Kinetic Parameters
| MMP | 105 kon (μM−1 s−1) | 103 koff (s−1) | Ki (μM) |
|---|---|---|---|
| MMP-2 | 8.5 ± 1.1 | 1.0 ± 0.2 | 11.7 ± 2.7 |
| MMP-9cat | 4.8 ± 0.6 | 1.7 ± 0.2 | 35.8 ± 6.7 |
| MMP-14cat | 3.9 ± 0.1 | 1.3 ± 0.1 | 32.6 ± 1.3 |
| MMP-1cat | 17% inhibition at 500 μM | ||
| MMP-7 | 43% inhibition at 500 μM | ||
| MMP-3cat | linear competitive | 142.1 ± 11.0 | |
