Skip to main content
. Author manuscript; available in PMC: 2018 Feb 6.
Published in final edited form as: Adv Exp Med Biol. 2017;1042:207–228. doi: 10.1007/978-981-10-6955-0_10

Fig. 10.2.

Fig. 10.2

Conformation changes proceeding from the inactive Mcm2-7 at an origin to Mcm2-7 in the active CMG helicase. The figure focuses on a side view of the Mcm2 and Mcm5 subunits in the Mcm2-7 hexamer in which one Mcm2-7 hexamer has been extracted from the inactive double hexamer (PDB 3JA8) (left side) and the Mcm2-7 hexamer has been extracted from the active CMG structure (PDB 3JC7) (middle). The two Mcm2-7 structures are then superimposed (right side). Structures are in cartoon view wrapped in a dim gray surface view. Mcm5 is gold and Mcm2 is blue. The Mcm2/5 interface is nearly opened in Mcm2-7 within CMG