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. Author manuscript; available in PMC: 2018 Feb 6.
Published in final edited form as: Adv Exp Med Biol. 2017;1042:207–228. doi: 10.1007/978-981-10-6955-0_10

Fig. 10.4.

Fig. 10.4

Comparison of the yeast and human Cdc45 structures. (a) The domain structure of Cdc45. (b) Cartoon view of the yeast Cdc45 structure extracted from the CMG structure (PDB 3JC6), with each domain colored according to the domain sketch in (a). PHM refers to protruding helical motif. (c) Superimposition of the yeast and human Cdc45 structures. Human Cdc45 is shown in light purple (PDB 5DGO). (d) Human Cdc45 point mutations identified in patients with Meier-Gorlin syndrome are highlighted as spheres