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. Author manuscript; available in PMC: 2018 Feb 6.
Published in final edited form as: Adv Exp Med Biol. 2017;1042:207–228. doi: 10.1007/978-981-10-6955-0_10

Fig. 10.7.

Fig. 10.7

Selected 2D class averages of several replisome complexes. (a) The Ctf4 trimer binds to the GINS from the bottom NTD side of CMG. (b) Pol α-primase appears as a fuzzy density suggesting a flexible association with the Ctf4 just under the NTD ring of Mcm2-7. (c) Simultaneous binding of Pol ε to the CTD side of Mcm2-7 on top and the Ctf4 trimer to the NTD side of CMG. (d) Pol ε binds to the CTD side of CMG in the presence of a primed forked DNA. (e) Pol ε binds to the CTD side of CMG, while Ctf4 and Pol α bind to the NTD side of CMG (This figure is modified with permission from Figure 5 of Sun et al. 2015)