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. 2018 Feb 5;217(2):571–583. doi: 10.1083/jcb.201706101

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© 2018 Kavaler et al.

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Figure 4. — Endogenous expression of either mir-279 or mir-996 fully rescues the mir-279/996 double mutant. (A) Summary of 16.6-kb genomic rescue transgenes bearing a wild-type mir-279/996 sequence or that have been modified to produce only mir-279 or only mir-996. These were assayed in the mir-279/996[15C/15C] deletion background. (B–F) Staining of ∼32 h APF nota with the socket cell marker Su(H), the shaft/sheath cell marker DPax2, and the neuronal marker Elav. (B) Wild-type pattern. (C) mir-279/996[15C/15C] shows high-frequency conversion of small DPax2 nuclei (sheath) into ectopic neurons (circled organs), whereas outer cell fates (socket and shaft) are relatively unaffected. This defect is fully rescued by wild-type mir-279/996 transgene (D), mir-279-only transgene (E), and mir-996-only transgene (F). Bars, 50 µM.