Table 2.

Trend of Serum and Urine Osmolalities, Electrolytes, Serum Sodium, and Specific Gravity

Day	Days After Starting Avelumab Treatment								Normal Range
	126	132	148	168	170	182	196	224
U Osm (mOsm/Kg)	241	380	382	467	493	505	557	596	300–900
S Osm (mOsm/Kg)	303	303	296	298	299	300	299	298	278–298
S Sodium (mmol/L)	147	144	142	143	142	144	142	141	136–145
Sp Gravity	1.00	1.01				1.01	1.011	1.016	1.002–1.035

The patient presented with DI symptoms on day 126 after starting avelumab and received DDAVP from day 132 to day 167 (shaded days).

Abbreviations: S Osm, serum osmolality; Sp Gravity, urine specific gravity; S Sodium, serum sodium; U Osm, urine osmolality.