Table 3. Genes reported to be linked to poor prognosis in ACC tumors.
| Gene | Reference | Correlated to | Methods* | HR** | 95% C.I. | p-value | |
|---|---|---|---|---|---|---|---|
| BMI1 | [34] | Poor Outcome | IHC | 0.98 | 0.59 | 1.61 | 0.929 |
| CDH1 | [34] | Good Outcome | IHC | 1.08 | 0.12 | 9.43 | 0.945 |
| EN1 | [30] | Poor Outcome | IHC | 2.82 | 0.66 | 12.01 | 0.160 |
| EPAS1 (HIF2a) | [35] | Poor Outcome | QPCR, IHC | 0.16 | 0.02 | 1.25 | 0.081 |
| FABP7 | [61] | Poor Outcome | QPCR | 2.20 | 0.83 | 5.81 | 0.111 |
| ILK | [36] | Poor Outcome | IHC | 0.57 | 0.09 | 3.73 | 0.555 |
| KIT | [37] | Poor Outcome | QPCR | 1.13 | 0.17 | 7.42 | 0.897 |
| MYB | [1] | Poor Outcome | QPCR | 3.59 | 0.95 | 13.53 | 0.059 |
| NOTCH1 | [38] | Poor Outcome | IHC | 2.11 | 0.08 | 54.54 | 0.653 |
| PDCD4 | [39] | Good Outcome | IHC | 0.68 | 0.21 | 2.26 | 0.531 |
| PIM1 | [40] | Poor Outcome | IHC | 0.57 | 0.20 | 1.58 | 0.277 |
| PPM1D (WIP1) | [41] | Poor Outcome | IHC | 1.79 | 0.55 | 5.84 | 0.333 |
| PTEN | [36] | Good Outcome | IHC | 0.19 | 0.01 | 3.27 | 0.252 |
| PTK2 (FAK) | [36] | Poor Outcome | IHC | 126.26 | 2.89 | 5507.29 | 0.012 |
| SNAI1 (Snail) | [34] | Poor Outcome | IHC | 0.94 | 0.60 | 1.47 | 0.790 |
| SNAI2 (Slug) | [34] | Poor Outcome | IHC | 0.34 | 0.13 | 0.91 | 0.032 |
| SOD2 | [42] | Poor Outcome | IHC | 0.55 | 0.10 | 2.98 | 0.492 |
| SOX2 | [43] | Poor Outcome | QPCR | 0.65 | 0.36 | 1.16 | 0.144 |
| TWIST2 | [35] | Poor Outcome | QPCR, IHC | 0.85 | 0.50 | 1.43 | 0.529 |
| ZEB2 (SIP1) | [35] | Poor Outcome | QPCR, IHC | 0.48 | 0.07 | 3.24 | 0.453 |
*IHC = Immunohistochemistry; QPCR = Quantitative PCR or other PCR assay.
**HR = Hazard Ratio for one standard deviation increase of gene expression in log scale.