Table 3. Relationship between FOXO6 transcript level and classical biological parameters in a series of 527 breast tumors.
| Clinical biological parameters | Number of patients (%) | p-valuea | ||
|---|---|---|---|---|
| Total population |
FOXO6 mRNA expression ˂ 3 relative to normal |
FOXO6 mRNA expression ≥ 3 relative to normal | ||
| Total | 527 (100) | 385 (73.1) | 142 (26.9) | |
| Age ≤50 >50 |
125 (23.7) 402 (76.3) |
99 (79.2) 286 (71.1) |
26 (20.8) 116 (28.9) |
0.076 (NS) |
| SBR histological gradeb,c I II III |
60 (11.7) 241 (47.1) 211 (41.2) |
42 (70) 187 (77.6) 145 (68.7) |
18 (30) 54 (22.4) 66 (31.3) |
0.088 (NS) |
| Lymph node statusd 0 1–3 >3 |
159 (30.5) 250 (47.9) 113 (21.6) |
114 (71.7) 179 (71.6) 88 (77.9) |
45 (28.3) 71 (28.4) 25 (22.1) |
0.42 (NS) |
| Macroscopic tumor sizee ≤25 mm >25 mm |
248 (48) 269 (52) |
181(73) 197 (73.2) |
67 (27) 72 (26.8) |
0.95 (NS) |
| ERα status Negative Positive |
181 (34.3) 346 (65.7) |
140 (77.3) 245 (70.8) |
41 (22.7) 101 (29.2) |
0.11 (NS) |
| PR status Negative Positive |
255 (48.4) 272 (51.6) |
197 (77.2) 188 (69.1) |
58 (22.7) 84 (30.9) |
0.035 |
| ERBB2 status Negative Positive |
397 (75.3) 130 (24.7) |
297 (74.8) 88 (67.7) |
100 (25.2) 42 (32.3) |
0.11 (NS) |
| Molecular subtypes HR– ERBB2– HR– ERBB2+ HR+ ERBB2– HR+ ERBB2+ |
102 (19.4) 72 (13.7) 295 (56) 58 (11) |
82 (80.4) 52 (72.2) 215 (72.9) 36 (62.1) |
20 (19.6) 20 (27.8) 80 (27.1) 22 (37.9) |
0.093 (NS) |
| Histological typesf Ductal Lobular Other |
398 (89.6) 28 (6.3) 18 (4.1) |
294 (73.9) 20 (71.4) 14 (77.8) |
104 (26.1) 8 (28.6) 4 (22.2) |
0.89 (NS) |
| MKI67 mRNA expressionh Median (range) |
12.5 (0.8–313) | 11.91 (0.8–313) | 14.05 (1.74–117.3) | 0.027 i |
| Metastasis No Yes |
317 (60.2) 210 (39.8) |
229 (72.2) 156 (74.3) |
88 (27.8) 54 (25.7) |
0.60 (NS) |
a: Chi-squared Test; b: Scarff Bloom Richardson classification; c: information available for 512 patients; d: information available for 522 patients; e: information available for 517 patients; f: information available for 444 patients; h: information available for 438 patients; i: Mann-Whitney’s U test. Abbreviations: NS: not significant; ERα: estrogen receptor alpha; PR: progesteron receptor; ERBB2: human epidermal growth factor receptor 2; HR: hormone receptor.