Table 2. Baseline characteristics of enrolled patients.
Total | No. of patients (%) | Captured CTC/mL | ||
---|---|---|---|---|
61 (100) | A cells (DAPI+/E&M+/CD45-/HE4+) | B cells (DAPI+/E&M-/CD45-/HE4+) | C cells (DAPI+/E&M+/CD45-/HE4-) | |
Tumor stage (Kruskal-Wallis test) | p = 0.064 | p = 0.105 | p = 0.742 | |
Benign | 25 (41.0) | 0.8 ± 1.5 (0–6) | 0.1 ± 0.6 (0–3) | 2.7 ± 6.6 (0–31) |
Stage I | 8(13.2) | 2.1 ± 1.8 (0–6) | 0.0 ± 0.0 (0–0) | 2.5 ± 3.4 (0–8) |
Stage II | 4 (6.6) | 2.0 ± 2.1 (0–5) | 0.3 ± 0.5 (0–1) | 2.0 ± 2.4 (0–5) |
Stage III | 16 (26.4) | 2.3 ± 2.5(0–8) | 0.06 ± 0.3 (0–1) | 2.3 ± 4.2 (0–15) |
Stage IV | 2 (3.3) | 1.0 ± 1.4 (0–2) | 0.5 ± 0.71 (0–1) | 0.0 ± 0.0 (0) |
Other malignant diseases | 6 (9.8) | 0.5 ± 0.8 (0–2) | 0.0 ± 0.0 (0–0) | 2.8 ± 4.2 (0–11) |
Macroscopic residual disease* (t-test) | p = 0.741 | p = 0.364 | p = 0.776 | |
Yes | 10 (34.5) | 2.2 ± 2.3 (0–8) | 0.1 ± 0.3 (0–1) | 2.4 ± 3.2 (0–10) |
No | 19 (65.5) | 2.1 ± 2.2 (0–7) | 0.1 ± 0.2 (0–1) | 2.2 ± 3.9 (0–15) |
Lymph node involvement* (ANOVA) | p = 0.53 | p <0.001 | p = 0.117 | |
Yes | 7 (23.3) | 3.0 ± 2.5 (0–7) | 0.1 ± 0.4 (0–1) | 3.0 ± 5.4 (0–15) |
No | 17 (56.7) | 2.1 ± 2.3 (0–8) | 0.0 ± 0.0 (0) | 2.4 ± 3.3 (0–10) |
Unmeasured† | 6 (20) | 1.3 ± 1.2 (0–3) | 0.3 ± 0.5 (0–1) | 0.5 ± 1.2 (0–3) |
CA-125 (t-test) | p = 0.966 | p = 0.635 | p = 0.724 | |
≤ 35 U/mL | 21 (36.7) | 1.5 ± 2.2 (0–8) | 0.1 ± 0.7 (0) | 1.7 ± 3.4 (0–15) |
> 35 U/mL | 36 (63.3) | 1.5 ± 1.9 (0–7) | 0.1 ± 0.3 (0–1) | 2.1 ± 3.5 (0–10) |
*Benign samples were not included for these characteristics.
†Did not undergo the surgery or lymph node dissection.