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. 2018 Jan 4;9(7):7522–7533. doi: 10.18632/oncotarget.23943

Table 3. Statistic results of the ROC curve analysis.

Cutoff point Area under curve Sensitivity Specificity p-value
A: In all patients
A cell 0.5 0.716 0.733 0.630 0.005
B cell 0.5 0.530 0.100 0.963 0.701
C cell 2.5 0.538 0.300 0.852 0.620
A + B cell 0.5 0.715 0.767 0.630 0.005
A + C cell 2.5 0.661 0.533 0.741 0.037
A + B + C cell 3.5 0.534 0.300 0.889 0.660
CA125 98.55 0.691 0.567 0.815 0.013
B: In CA125 normal patients†
A cell 0.5 0.653 0.778 0.583 0.241
B cell 0.5 0.458 0.000 1.000 0.749
C cell 3.5 0.551 0.333 0.917 0.696
A + B cell 0.5 0.616 0.778 0.583 0.374
A + C cell 11 0.583 0.222 1.000 0.522
A + B + C cell 3.5 0.519 0.333 0.917 0.887
C: In CA125 elevated patients†
A cell 1.5 0.767 0.571 0.867 0.007
B cell 0.5 0.571 0.143 1.000 0.470
C cell 2.5 0.517 0.286 0.867 0.860
A + B cell 2.5 0.790 0.476 1.000 0.003
A + C cell 2.5 0.689 0.619 0.733 0.056
A + B + C cell 3.0 0.533 0.286 0.867 0.736

A cell: DAPI+/E&M+/CD45-/HE4+ cells; B cell: DAPI+/E&M-/CD45-/HE4+ cells; C cell: DAPI+/E&M+/CD45-/HE4- cells; A + B cell: DAPI+/CD45-/HE4+ cells; A + C cell: DAPI+/E&M+/CD45- cells; A + B + C cell: DAPI+/CD45-cells.

CA125 value was estimated as “normal” and “elevated” based on cutoff, 35 U/mL;