Table 3. Statistic results of the ROC curve analysis.
Cutoff point | Area under curve | Sensitivity | Specificity | p-value | |
---|---|---|---|---|---|
A: In all patients | |||||
A cell | 0.5 | 0.716 | 0.733 | 0.630 | 0.005 |
B cell | 0.5 | 0.530 | 0.100 | 0.963 | 0.701 |
C cell | 2.5 | 0.538 | 0.300 | 0.852 | 0.620 |
A + B cell | 0.5 | 0.715 | 0.767 | 0.630 | 0.005 |
A + C cell | 2.5 | 0.661 | 0.533 | 0.741 | 0.037 |
A + B + C cell | 3.5 | 0.534 | 0.300 | 0.889 | 0.660 |
CA125 | 98.55 | 0.691 | 0.567 | 0.815 | 0.013 |
B: In CA125 normal patients† | |||||
A cell | 0.5 | 0.653 | 0.778 | 0.583 | 0.241 |
B cell | 0.5 | 0.458 | 0.000 | 1.000 | 0.749 |
C cell | 3.5 | 0.551 | 0.333 | 0.917 | 0.696 |
A + B cell | 0.5 | 0.616 | 0.778 | 0.583 | 0.374 |
A + C cell | 11 | 0.583 | 0.222 | 1.000 | 0.522 |
A + B + C cell | 3.5 | 0.519 | 0.333 | 0.917 | 0.887 |
C: In CA125 elevated patients† | |||||
A cell | 1.5 | 0.767 | 0.571 | 0.867 | 0.007 |
B cell | 0.5 | 0.571 | 0.143 | 1.000 | 0.470 |
C cell | 2.5 | 0.517 | 0.286 | 0.867 | 0.860 |
A + B cell | 2.5 | 0.790 | 0.476 | 1.000 | 0.003 |
A + C cell | 2.5 | 0.689 | 0.619 | 0.733 | 0.056 |
A + B + C cell | 3.0 | 0.533 | 0.286 | 0.867 | 0.736 |
A cell: DAPI+/E&M+/CD45-/HE4+ cells; B cell: DAPI+/E&M-/CD45-/HE4+ cells; C cell: DAPI+/E&M+/CD45-/HE4- cells; A + B cell: DAPI+/CD45-/HE4+ cells; A + C cell: DAPI+/E&M+/CD45- cells; A + B + C cell: DAPI+/CD45-cells.
†CA125 value was estimated as “normal” and “elevated” based on cutoff, 35 U/mL;