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. 2018 Jan 10;9(7):7590–7603. doi: 10.18632/oncotarget.24136

Table 5. Interaction between physical activity based on MET-minutes per week and PITX1 genetic variant in the risk of CRC stratified by anatomical sites and gender.

CC AC/AA P–interaction
Low Moderate High Low Moderate High
Colorectal cancer
All
 No. controls/cases 222/106 213/111 235/77 219/126 229/157 208/108
 Crude OR (95% CI) 1.00 (ref.) 1.09 (0.79–1.51) 0.69 (0.49–0.97) 1.21 (0.88–1.66) 1.44 (1.06–1.95) 1.09 (0.78–1.51) 0.263
 Adjusted ORa (95% CI) 1.00 (ref.) 0.97 (0.67–1.40) 0.56 (0.38–0.82) 1.28 (0.90–1.83) 1.29 (0.91–1.82) 0.81 (0.56–1.17) 0.649
Male
 No. controls/cases 162/109 143/48 166/49 159/120 140/65 135/76
 Crude OR (95% CI) 1.00 (ref.) 0.50 (0.33–0.75) 0.44 (0.29–0.66) 1.12 (0.80–1.58) 0.69 (0.47–1.01) 0.84 (0.58–1.21) 0.052
 Adjusted ORb (95% CI) 1.00 (ref.) 0.48 (0.30–0.76) 0.34 (0.21–0.54) 1.17 (0.79–1.73) 0.63 (0.41–0.97) 0.63 (0.41–0.96) 0.157
Female
 No. controls/cases 72/17 63/37 64/34 65/27 79/58 78/45
 Crude OR (95% CI) 1.00 (ref.) 2.49 (1.28–4.84) 2.25 (1.15–4.41) 1.76 (0.88–3.52) 3.11 (1.66–5.83) 2.44 (1.28–4.65) 0.284
 Adjusted ORb (95% CI) 1.00 (ref.) 2.14 (1.03–4.44) 1.79 (0.84–3.78) 2.06 (0.96–4.41) 3.08 (1.55–6.12) 1.62 (0.79–3.32) 0.091
Colon cancer
All
 No. controls/cases 222/49 213/53 235/44 219/64 229/84 208/54
 Crude OR (95% CI) 1.00 (ref.) 1.13 (0.73–1.74) 0.85 (0.54–1.33) 1.32 (0.87–2.01) 1.66 (1.12–2.47) 1.18 (0.77–1.81) 0.854
 Adjusted ORa (95% CI) 1.00 (ref.) 1.01 (0.64–1.60) 0.69 (0.43–1.12) 1.40 (0.90–2.18) 1.50 (0.98–2.31) 0.89 (0.56–1.41) 0.903
Male
 No. controls/cases 162/49 143/22 166/28 159/53 140/35 135/41
 Crude OR (95% CI) 1.00 (ref.) 0.51 (0.20–0.88) 0.56 (0.33–0.93) 1.10 (0.71–1.72) 0.83 (0.51–1.35) 1.00 (0.63–1.61) 0.148
 Adjusted ORb (95% CI) 1.00 (ref.) 0.48 (0.27–0.88) 0.43 (0.24–0.75) 1.14 (0.71–1.85) 0.75 (0.44–1.27) 0.77 (0.46–1.30) 0.165
Female
 No. controls/cases 72/8 63/18 64/21 65/19 79/31 78/23
 Crude OR (95% CI) 1.00 (ref.) 2.57 (1.05–6.32) 2.95 (1.22–7.13) 2.63 (1.08–6.42) 3.53 (1.52–8.18) 2.65 (1.12–6.31) 0.064
 Adjusted ORb (95% CI) 1.00 (ref.) 2.12 (0.81–5.53) 2.22 (0.85–5.75) 3.10 (1.19–8.06) 3.39 (1.39–8.29) 1.63 (0.64–4.14) 0.028
Rectal cancer
All
 No. controls/cases 222/57 213/57 235/32 219/57 229/72 208/53
 Crude OR (95% CI) 1.00 (ref.) 1.04 (0.69–1.57) 0.53 (0.33–0.85) 1.01 (0.67–1.53) 1.23 (0.83–1.82) 0.99 (0.65–1.51) 0.068
 Adjusted ORa (95% CI) 1.00 (ref.) 0.91 (0.58–1.43) 0.42 (0.25–0.70) 1.10 (0.70–1.71) 1.08 (0.70–1.66) 0.72 (0.46–1.14) 0.196
Male
 No. controls/cases 162/60 143/26 166/20 159/65 140/30 135/35
 Crude OR (95% CI) 1.00 (ref.) 0.49 (0.29–0.82) 0.33 (0.19–0.56) 1.10 (0.73–1.67) 0.58 (0.35–0.95) 0.70 (0.44–1.13) 0.081
 Adjusted ORb (95% CI) 1.00 (ref.) 0.47 (0.27–0.84) 0.25 (0.14–0.46) 1.16 (0.73–1.84) 0.52 (0.30–0.90) 0.50 (0.30–0.85) 0.166
Female
 No. controls/cases 72/9 63/19 64/12 65/6 79/25 78/21
 Crude OR (95% CI) 1.00 (ref.) 2.41 (1.02–5.71) 1.50 (0.59–3.79) 0.74 (0.25–2.19) 2.53 (1.10–5.78) 2.15 (0.93–5.01) 0.472
 Adjusted ORb (95% CI) 1.00 (ref.) 2.17 (0.87–5.40) 1.26 (0.47–3.40) 0.87 (0.28–2.69) 2.57 (1.08–6.13) 1.60 (0.65–3.96) 0.648

aAdjusted for age, gender, education, alcohol, family history of CRC, total energy intake.

bAdjusted for age, education, alcohol, family history of CRC, total energy intake.

Physical activity-All: <1116 (low), 1116-<2925 (moderate), ≥2925 (High)

Physical activity-Male: <1386 (low), 1386-<3465 (moderate), ≥3465 (High)

Physical activity-Female: <660 (low), 660-<2079 (moderate), ≥2079 (High)