Table 2.
Distribution of urinary metabolite or molar sum concentrations among 136 women undergoing assisted reproduction.1
| Parent compound | Metabolite | Units | LOD | % Detect | SG-adjusted2 Median (IQR) | Max | Unadjusted Median (IQR) | Max |
|---|---|---|---|---|---|---|---|---|
| DEHP | ΣDEHP MEHP MEHHP MEOHP MECPP |
μmol/L μg/L μg/L μg/L μg/L |
0.8 0.4 0.2 0.4 |
– 91.2% 100% 100% 100% |
0.16 (0.11, 0.27) 3.5 (2.2, 7.6) 13.2 (8.6, 22.2) 9.6 (6.4, 16.1) 19.7 (13.3, 33.6) |
2.7 71 215 145 371 |
0.17 (0.08, 0.28) 3.8 (1.6, 8.4) 12.8 (7.2, 23.7) 9.9 (5.1, 16.9) 20.1 (10.4, 35.1) |
2.8 66 230 155 398 |
| DEP | MEP | μg/L | 1.2 | 100% | 181.7 (71.1, 431.2) | 9333 | 150.5 (61.7, 374.5) | 10000 |
| DBP or DnBP | MBP MHBP |
μg/L μg/L |
0.4 0.4 |
98.5% 88.2% |
18.8 (11.5, 32.0) 1.3 (0.8, 2.3) |
148 17 |
17.4 (8.9, 35.5) 1.2 (0.6, 2.4) |
212 18 |
| DOP (DBP, minor) | MCPP | μg/L | 0.4 | 90.4% | 1.2 (0.7, 2.2) | 130 | 1.2 (0.6, 2.2) | 233 |
| DiBP | MiBP MHiBP |
μg/L μg/L |
0.8 0.4 |
99.3% 100% |
24.0 (15.9, 38.5) 6.6 (3.8, 13.2) |
188 65 |
24.9 (12.8, 41.7) 7.5 (4.8, 13.2) |
205 75 |
| BBzP | MBzP | μg/L | 0.3 | 77.2% | 1.8 (1.0, 2.8) | 382 | 1.9 (0.8, 3.2) | 682 |
| DiNP | MCOP MiNP MONP |
μg/L μg/L μg/L |
0.3 0.9 0.4 |
100% 51.5% 97.8% |
8.2 (5.3, 17.1) 1.0 (<LOD, 1.6) 3.5 (2.4, 6.0) |
1344 263 902 |
8.2 (5.0, 14.6) 0.9 (<LOD, 1.8) 3.5 (1.8, 6.6) |
2400 470 1610 |
| DiDP | MCNP | μg/L | 0.2 | 98.5% | 1.1 (0.7, 2.1) | 46 | 1.1 (0.7, 2.1) | 82 |
| DINCH | MHiNCH MCOCH |
μg/L μg/L |
0.4 0.5 |
92.6% 68.4% |
1.1 (0.7, 2.4) 0.6 (<LOD, 1.3) |
75 27 | 1.2 (0.7, 2.1) 0.6 (<LOD, 0.9) |
30 10 |
| DEHTP | MEHHTP MECPTP |
μg/L μg/L |
0.4 0.2 |
90.4% 100% |
2.4 (1.2, 4.6) 8.2 (4.3, 16.8) |
386 2856 | 2.3 (1.0, 4.7) 7.7 (4.2, 15.7) |
140 1020 |
Abbreviations: IQR, interquartile range; LOD, limit of detection; min, minimum; max, maximum; SG, specific gravity.
Out of the 136 women, 99 (72.8%) women had 2 pooled urine samples from the day of stimulation and the day of retrieval, 36 (26.5%) women had one urine sample from the day of retrieval, and one (0.7%) woman had one urine sample from the day of stimulation.
Instrumental reading values were used for metabolite concentrations below the LOD. To adjust for urinary dilution, we used the following formula: Pc = P[(1.014 − 1)/SG − 1], where Pc is the SG-corrected metabolite concentration (μg/L), P is the measured metabolite concentration (μg/L), and 1.014 is the mean SG level in our study population.