Table 4.

Associations between urinary concentrations of metabolites of low molecular weight phthalates and intermediate outcomes of assisted reproduction (n=136 women/cycles).

		Adjusted Mean (95% CI)¹
SG-adjusted Phthalate Metabolite Concentration (Range)	N	Total Oocytes	Mature Oocytes	Fertilized Oocytes	Top Quality Embryos
MEP (μg/L)
T1 (12.9–91.7)	45	10.8 (9.9, 11.9)	8.7 (7.8, 9.6)	5.8 (5.1, 6.6)	2.6 (2.1, 3.1)
T2 (91.8–286)	46	10.2 (9.3, 11.1)	8.2 (7.4, 9.0)	5.5 (4.9, 6.3)	2.3 (1.9, 2.8)
T3 (287–9333)	45	7.8 (7.0, 8.6)^*^†	6.4 (5.7, 7.2)^*^†	4.3 (3.7, 5.0)^*^†	2.2 (1.8, 2.7)
P-trend²		<0.001	<0.001	<0.001	0.38
MBP (μg/L)
T1 (0.00–12.7)	45	10.9 (10.0, 11.9)	8.6 (7.7, 9.5)	5.8 (5.2, 6.6)	2.8 (2.4, 3.4)
T2 (12.8–26.6)	46	9.7 (8.8, 10.6)	7.9 (7.1, 8.7)	5.3 (4.7, 6.0)	2.1 (1.7, 2.6)^*
T3 (26.7–148)	45	8.2 (7.4, 9.1)^*^†	6.8 (6.1, 7.6)^*	4.5 (3.9, 5.2)^*	2.2 (1.8, 2.6)^*
P-trend		<0.001	0.002	0.006	0.07
MHBP (μg/L)
T1 (0.00–0.93)	46	8.1 (8.0, 9.8)	7.2 (6.5, 8.0)	4.9 (4.3, 5.6)	2.3 (1.9, 2.8)
T2 (0.94–1.87)	45	11.3 (10.4, 12.3)^*	8.9 (8.1, 9.8)^*	6.1 (5.4, 6.9)^*	2.8 (2.4, 3.4)
T3 (1.88–17.1)	45	8.7 (7.8, 9.6)^†	7.1 (6.4, 7.9)^†	4.7 (4.1, 5.3)^†	1.9 (1.6, 2.4)^†
P-trend		0.17	0.32	0.22	0.09
MiBP (μg/L)
T1 (0.28–17.9)	45	10.6 (9.6, 11.6)	8.5 (7.7, 9.4)	5.8 (5.1, 6.6)	2.9 (2.4, 3.4)
T2 (18.0–31.1)	46	8.7 (7.9, 9.6)^*	6.7 (6.0, 7.5)^*	4.6 (4.0, 5.3)*	2.0 (1.7, 2.5)^*
T3 (31.2–188)	45	9.5 (8.7, 10.5)	8.0 (7.2, 8.8)^†	5.3 (4.6, 6.0)	2.2 (1.8, 2.7)^*
P-trend		0.28	0.72	0.48	0.08
MHiBP (μg/L)
T1 (0.67–5.6)	45	9.5 (8.6, 10.5)	7.7 (6.9, 8.5)	5.2 (4.6, 6.0)	2.7 (2.2, 3.2)
T2 (5.7–10.4)	46	10.1 (9.2, 11.0)	8.0 (7.3, 8.9)	5.5 (4.9, 6.3)	2.5 (2.2, 3.0)
T3 (10.5–75)	45	9.2 (8.3, 10.1)	7.5 (6.7, 8.3)	4.9 (4.3, 5.6)	2.0 (1.6, 2.4)
P-trend		0.46	0.61	0.32	0.03

Models were run using Poisson regression with log link. All data are presented as adjusted mean counts controlling for maternal age, body mass index, and current smoking status.

p-value for T3 or T2 vs. T1 < 0.05;

^†

p-value for T3 vs. T2 < 0.05