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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Nov 24;1869(1):64–77. doi: 10.1016/j.bbcan.2017.11.005

Table 1.

Summary of papers demonstrating exosomes/EVs role in tumour metastasis

Cancer Type Target Molecules
involved
Type of study References
Bladder Cancer Urothelial cells --------- In vitro [95] Franzen et al., 2015. Oncogenesis

Breast Cancer CAFs Wnt11 In vivo [5] Hoffman et al., 2013. Breast Cancer Res

Breast hsp90α In vitro [75] McCready et al., 2010. BMC Cancer

Lung --------- In vitro and in vivo [17] Suetsugu et al., 2013. Adv Drug Deliv Rev

Lung Annexin II In vitro and in vivo [102] Maji et al., 2017. Mol Cancer Res

Lung miRNAs In vitro and in vivo [66] Kosaka et al., 2013. J. Biol Chem
In vitro [6] Zhou et al., 2014. Cancer Cell

Lung cytokine Ex-vivo [7] Gorczynski et al., 2016 Cancer Med
Liver

Lymph nodes mRNAs In vitro and ex-vivo [171] Rodríguez et al., 2015. Oncotarget
Lung
Brain

Colorectal Cancer Liver CXCR4 In vitro and in vivo [172] Wang et al., 2015. Oncol Rep

Endothelial cells mRNA In vitro [173] Hong et al., 2009. BMC Genomics

--------- proteins In vitro [174] Choi et al., 2012. J Extracell Vesicles

Duodenal Cancer --------- PABP1 In vitro [68] Ohshima et al., 2014. Proteomics

Esophageal Carcinoma esophagus --------- In vitro [175] Min et al., 2017. Pathol Oncol Res

Gastric Cancer --------- let-7 miRNA family In vitro [8][65] Ohshima et al., 2010. PLoS ONE

Liver EGFR In vivo and ex-vivo [176] Zhang et al., 2017. Nat Commun

Lymph node CD97 In vitro [177] Liu et al., 2016. Gastric Cancer

Glioma -------- miR-21 Ex-vivo [178] Shi et al., 2015. Oncotarget

Hepatocellular Carcinoma Hepatocyte Proteins RNAs In vitro [179] He et al., 2015. Carcinogenesis

Lung Bone miRNAs In vitro and in vivo [180] Valencia et al., 2014. Mol Oncol.

Lung Small nuclear RNA Ex-vivo [181] Liu et al., 2016. Cancer Cell

Lymph node periostin In vitro [182] Vardaki et al., 2016. Oncotarget

Melanoma --------- In vitro [126] Parolini et al., 2009. J Biol Chem.

--------- miRNAs Ex-vivo [183] Pfeffer et al., 2015. J Clin Med

Bone marrow --------- Ex-vivo [19] Peinado et al., 2012. Nat Med

Lung Met 72 In vitro and ex-vivo [184] Hao et al., 2006. Exp Oncol
Met In vitro and in vivo [185] Adachi et al., 2016. Oncotarget

Lymph nodes miRNAs In vitro and ex-vivo [101] Hood et al., 2011. Cancer Res
HIF-1α Ex-vivo [186] Hood et al., 2016. Med Hypotheses

Nasopharyngeal Carcinoma -------- HIF1α In vitro [187] Aga et al., 2014. Oncogene

Stromal cells MMP13 In vitro [97] You et al., 2015. Cancer Sci

Non-small cell lung cancer bone AREG In vitro and ex-vivo [188] Taverna et al., 2017. Sci Rep

Oral Squamous Lymph node miR-21 In vitro and in vivo [189] Li et al., 2016. Cancer Res
Cell Carcinoma

Pancreatic ductal adenocarcinoma Liver MIF In vivo and in vivo [190] Costa-Silva et al., 2015. Nat Cell Biol

Prostate Cancer Prostate miRNAs In vitro [191] Sánchez et al., 2016. Oncotarget

Prostate αvβ6 In vitro [192] Fedele et al., 2015. J Biol Chem

Rat pancreatic adenocarcinoma Lymph nodes CD44v6 In vitro and in vivo [37] Jung et al., 2009. Neoplasia
Lung In vitro and in vivo [193] Wang et al., 2013. Int J Cancer

Lymph nodes mRNAs In vitro and in vivo [194] Rana et al., 2013. Neoplasia N.Y.
miRNAs

Renal Carcinoma Lung CD105 In vitro and in vivo [39] Grange et al., 2011. Cancer Res