Table 2.

Function and significance of 14 other proteins in the Molecular Mechanisms of Cancer Pathway

Protein	Function/Significance	Reference
RAP2B	RAP2B is a member of RAS oncogene family and is highly expressed in HCC tissue.	Zhang et al., 2017
NAIP	NAIP is a member of the Inhibitors of apoptosis proteins (IAPs) family. NAIP mRNA has a slightly lower expression level in cancer tissue (FC =0.67)	Augello et al., 2009
FYN	FYN is a non-receptor tyrosine kinase that belongs to the Src family kinases (SFKs). FYN’s expression is observed in various cancers.	Elias et al., 2015
PAK6	PAK6 is a member of the p21-activated kinases. PAK6 might be a tumor suppressor gene in HCC.	Liu et al., 2015
BAX	BAX is a pro-apoptotic member of the BCL2 family. Increased expression is correlated with good prognosis in HCC.	Garcia et al., 2002
CDKN2B	CDKN2B are potent inhibitors of the cyclin D complex and function as tumor suppressors. Gene deletion is found in 13% HCC.	Lin et al., 1998
DIABLO	DIABLO is a pro-apoptogenic mitochondrial protein. Expression is reduced in HCC.	Bao et al., 2006
RASGRF2	RASGRF2 is a nucleotide exchange factor that activates the RAS pathway. The protein expression is reduced in lung cancer.	Chen et al., 2006
GNA15	GNA15 is a guanine nucleotide binding protein involved in prostate cancer development.	Haibi et al., 2013
PIK3CB	PIK3CB is a member of the phosphoinositide 3-kinases. PIK3CB is most likely upregulated in HCC.	Lang et al., 2012
BRCA1	BRCA1 is a protein involved in repairing damaged DNA and has low expression in HCC.	Ferroudj et al., 2016
MAP2K1	MAP2K1 is a mitogen-activated protein kinase and is upregulated in HCC.	Janku et al., 2014
CDK2	CDK2 is a cyclin-dependent kinase that its expression is elevated in HCC.	Li et al., 2002
ATM	ATM is a serine/threonine protein kinase that phosphorylates proteins involved in repairing damaged DNA. ATM is impaired in HCC.	Liu et al., 2017