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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2017 Nov 13;114:105–115. doi: 10.1016/j.yjmcc.2017.11.006

Figure 6.

Figure 6

JNK leads to suppressed Cx43 mRNA expression and reduced AP-1 activity. A–C. Pooled quantitative qPCR data showing downregulated Cx43 mRNA expression in both aged human and rabbit atria as well as AdMKK7D overexpressed HL-1 myocytes compared to controls. D. Pooled quantitative immunoblotting data showing increased phosphorylation of JNK downstream transcription factor c-jun (c-jun-P) and unchanged ATF2 (ATF2-P) in AdMKK7D infected HL-1 atrial myocytes compared to AdLacZ-infected controls. E. Summarized data showing that AP-1 luciferase activity in anisomycin-treated HEK293 cells is positively correlated with Cx43 mRNA expression in anisomycin-treated HL-1 myocytes vs vehicle-controls (Vehicle-Ctl).