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. Author manuscript; available in PMC: 2019 Jan 20.
Published in final edited form as: Eur J Med Chem. 2017 Dec 8;144:359–371. doi: 10.1016/j.ejmech.2017.12.024

Scheme 2. Synthesis of 11–14a.

Scheme 2

aReagents and Conditions: (a) 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline or 1-cyclohexylpiperazine, K2CO3, CH3CN; (b) 1-Bromo-4-chlorobutane, KOH, TBAB, DMF.