Tables 5.
A – C: ClueGO Age Tables
| A) Age in Cerebellum | ||||||
| GOID | Ontology Source | GOTerm | Nr. Genes | % Assoc. Genes | Term P- value | Associated Genes Found |
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| Reactome:R-MMU-1428517 | Pathways | The citric acid (TCA) cycle and respiratory electron transport | 9 | 6.2 | 6.15E-10 | Atp5a1, Atp5b, Dld, Dlst, Ldhb, Mdh2, Ndufa12, Ndufs4, Ogdh |
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| Reactome:R-MMU-5663213 | Pathways | RHO GTPases Activate WASPs and WAVEs | 4 | 12.5 | 2.75E-06 | Actb, Arpc5, Grb2, Mapk1 |
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| Reactome:R-MMU-70895 | Pathways | Branched-chain amino acid catabolism | 10 | 4.1 | 3.52E-09 | Aspa, Dld, Dlst, Glud1, Glul, Ivd, Ogdh, Psma7, Psmb2, Psmb5 |
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| Reactome:R-MMU-71291 | Pathways | Metabolism of amino acids and derivatives | 10 | 4.1 | 3.52E-09 | Aspa, Dld, Dlst, Glud1, Glul, Ivd, Ogdh, Psma7, Psmb2, Psmb5 |
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| GO:0006091 | Biological Process | generation of precursor metabolites and energy | 15 | 4.3 | 1.49E-13 | Dld, Dlst, Eno1b, Eno2, Hk1, Mdh1, Mdh2, Ndufa12, Ndufs4, Ogdh, Pfkp, Pgam1, Pgk1, Pkm, Ppp1ca |
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| GO:0008064 | Biological Process | regulation of actin polymerization or depolymerization | 7 | 4.3 | 6.87E-07 | Arpc5, Cfl1, Grb2, Pfn1, Sh3bgrl3, Twf2, Wdr1 |
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| GO:0016836 | Molecular Function | hydro-lyase activity | 3 | 6.1 | 4.62E-04 | Car2, Eno1b, Eno2 |
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| GO:0021762 | Biological Process | substantia nigra development | 5 | 13.2 | 1.09E-07 | Actb, Cnp, Cox6b1, Hspa5, Mbp |
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| GO:0046164 | Biological Process | alcohol catabolic process | 3 | 6.5 | 3.83E-04 | Aldh2, Apoe, Gpd2 |
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| GO:0046496 | Biological Process | nicotinamide nucleotide metabolic process | 13 | 9.6 | 2.33E-16 | Dld, Eno1b, Eno2, Hk1, Ldhb, Mdh1, Mdh2, Me1, Ogdh, Pfkp, Pgam1, Pgk1, Pkm |
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| GO:1990204 | CellularComponent | oxidoreductase complex | 6 | 6.3 | 5.01E-07 | Dld, Dlst, Gpd2, Ndufa12, Ndufs4, Ogdh |
| B) Age in Hippocampus | ||||||
| GOID | Ontology Source | GOTerm | Nr. Genes | % Assoc. Genes | Term P-value | Associated Genes Found |
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| Reactome:R-MMU-111885 | Pathways | Opioid Signalling | 4 | 4.4 | 9.17E-05 | Gnao1, Gnb1, Marcks, Ppp1ca |
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| Reactome:R-MMU-399956 | Pathways | CRMPs in Sema3A signaling | 3 | 18.8 | 9.34E-06 | Crmp1, Crmp2, Crmp3 |
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| GO:0008064 | Biological Process | regulation of actin polymerization or depolymerization | 7 | 4.3 | 2.27E-07 | Arpc5, Capzb, Cttn, Dstn, Grb2, Pfn2, Wdr1 |
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| GO:0009167 | Biological Process | purine ribonucleoside monophosphate metabolic process | 11 | 4.2 | 6.39E-11 | Aprt, Atp5b, Cox5b, Eno1b, Ndufa10, Ndufs1, Ogdh, Park7, Pgam1, Pkm, Tpi1 |
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| GO:0009168 | Biological Process | purine ribonucleoside monophosphate biosynthetic process | 3 | 4.3 | 7.92E-04 | Aprt, Atp5b, Cox5b |
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| GO:0016836 | Molecular Function | hydro-lyase activity | 4 | 8.2 | 8.24E-06 | Aco2, Car2, Eno1b, Park7 |
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| GO:0044724 | Biological Process | single-organism carbohydrate catabolic process | 7 | 5.8 | 2.76E-08 | Eno1b, Gpd2, Ogdh, Pgam1, Pkm, Ppp1ca, Tpi1 |
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| GO:0098798 | Cellular Component | mitochondrial protein complex | 6 | 4.4 | 1.57E-06 | Atp5b, Cox5b, Etfa, Ndufa10, Ndufs1, Park7 |
| C) Age in Disomic | ||||||
| GOID | Ontology Source | GOTerm | Nr. Genes | % Assoc. Genes | Term P-value | Associated Genes Found |
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| Reactome:R-MMU-70263 | Pathways | Gluconeogenesis | 3 | 8.3 | 1.00E-05 | Eno1b, Eno2, Tpi1 |
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| GO:0016836 | Molecular Function | hydro-lyase activity | 3 | 6.1 | 2.56E-05 | Car2, Eno1b, Eno2 |
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| GO:0046164 | Biological | alcohol catabolic process | 3 | 6.5 | 2.11E-05 | Aldh2, Apoe, Tpi1 |
% Associated Genes indicates the percent of the genes defining a given GO term that were listed (as accessions) in the ClueGO spot list. The “Age in Trisomic” protein accessions did not map to any networks. See Supplementary Tables S5 for more details and subnetworks.