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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Neurobiol Aging. 2017 Nov 26;63:96–109. doi: 10.1016/j.neurobiolaging.2017.11.010

Tables 6.

A – D: ClueGO Region Tables

A) Region in Six-Month
GOID Ontology Source GOTerm Nr. Genes % Assoc. Genes Term P-value Associated Genes Found
Reactome:R-MMU-210991 Pathways Basigin interactions 4 8.0 7.22E-06 Actb, Dnm1, Crmp2, Ezr
GO:0008064 Biological Process regulation of actin polymerization or depolymerization 7 4.3 1.56E-07 Arpc2, Arpc5, Capzb, Cttn, Pfn2, Twf2, Wdr1
GO:0016836 Molecular Function hydro-lyase activity 3 6.1 2.47E-04 Aco2, Car2, Eno1b
GO:0021762 Biological Process substantia nigra development 3 7.9 1.15E-04 Actb, Ckb, Cox6b1
GO:0030516 Biological Process regulation of axon extension 4 4.8 5.42E-05 Apoe, Cttn, Crmp2, Twf2
GO:0044724 Biological Process single-organism carbohydrate catabolic process 7 5.8 1.89E-08 Eno1b, Gpd2, Hmgb1, Pfkp, Pgam1, Pkm, Pygm
GO:0046164 Biological Process alcohol catabolic process 3 6.5 2.04E-04 Aldh2, Apoe, Gpd2
GO:0048489 Biological Process synaptic vesicle transport 6 4.7 7.65E-07 Dnm1, Crmp2, Napb, Pfn2, Snap25, Stxbp1
B) Region in Twelve-Month
GOID Ontology Source GOTerm Nr. Genes % Assoc. Genes Term P-value Associated Genes Found
Reactome:R-MMU-1428517 Pathways The citric acid (TCA) cycle and respiratory electron transport 10 6.9 4.86E-10 Atp5a1, Etfa, Glo1, Mdh2, Ndufa10, Ndufa12, Ndufa8, Ndufs3, Ndufs4, Ndufs8
GO:0000502 Cellular Component proteasome complex 3 4.3 3.11E-03 Psmb2, Psmb5, Txnl1
Reactome:R-MMU-399956 Pathways CRMPs in Sema3A signaling 4 25.0 4.90E-07 Crmp1, Crmp2, Crmp3, Crmp4
GO:0008064 Biological Process regulation of actin polymerization or depolymerization 8 4.9 4.01E-07 Arpc2, Arpc5, Capzb, Cfl1, Pfn1, Pfn2, Sh3bgrl3, Wdr1
GO:0009636 Biological Process response to toxic substance 12 5.1 2.93E-10 Cnp, Gsta4, Hbb-b1, Mapk1, Mbp, Nefl, Pebp1, Prdx1, Prdx3, Sod1, Txnl1, Uba52
GO:0015036 Molecular Function disulfide oxidoreductase activity 3 7.3 6.61E-04 Pgk1, Sh3bgrl3, Txnl1
GO:0021761 Biological Process limbic system development 6 4.7 1.51E-05 Arpc5, Cfl1, Nefl, Pebp1, Uba52, Ywhae
GO:0021762 Biological Process substantia nigra development 6 15.8 1.08E-08 Actb, Ckb, Cnp, Mbp, Ndufs3, Ywhae
GO:0023026 Molecular Function MHC class II protein complex binding 3 18.8 3.74E-05 Hsp90aa1, Pkm, Ywhae
GO:0033267 Cellular Component axon part 9 4.6 1.18E-07 Cplx1, Crmp2, Mbp, Nefl, Pfn2, Sod1, Stxbp1, Syn1, Uchl1
GO:0042470 Cellular Component melanosome 7 6.7 2.78E-07 Atp6v1b2, Cnp, Erp29, Hsp90aa1, Hsp90b1, Prdx1, Ywhae
GO:0044275 Biological Process cellular carbohydrate catabolic process 5 14.7 2.81E-07 Gpd2, Hmgb1, Pgam1, Ppp1ca, Pygm
GO:0044306 Cellular Component neuron projection terminus 8 5.9 9.97E-08 Cplx1, Crmp2, Glul, Pebp1, Pfn2, Stxbp1, Syn1, Uchl1
GO:0044724 Biological Process single-organism carbohydrate catabolic process 7 5.8 6.91E-07 Gpd2, Hmgb1, Pgam1, Pgk1, Pkm, Ppp1ca, Pygm
C) Region in Disomic
GOID Ontology Source GOTerm Nr. Genes % Assoc. Genes Term P-value Associated Genes Found
Reactome:R-MMU-210991 Pathways Basigin interactions 4 8.0 3.51E-06 Actb, Dnm1, Crmp2, Ezr
Reactome:R-MMU-399956 Pathways CRMPs in Sema3A signaling 3 18.8 4.62E-06 Crmp1, Crmp2, Crmp4
GO:0031333 Biological Process negative regulation of protein complex assembly 5 4.1 5.58E-06 Capzb, Hmgb1, Pfn2, Stxbp1, Twf2
GO:0048489 Biological synaptic vesicle transport 6 4.7 2.58E-07 Dnm1, Crmp2, Napb, Pfn2, Snap25, Stxbp1
D) Region in Trisomic
GOID Ontology Source GOTerm Nr. Genes % Assoc. Genes Term P-value Associated Genes Found
Reactome:R-MMU-1428517 Pathways The citric acid (TCA) cycle and respiratory electron transport 6 4.1 2.41E-06 Aco2, Glo1, Mdh2, Ndufa10, Ndufa12, Ndufs8
Reactome:R-MMU-210991 Pathways Basigin interactions 5 10.0 2.19E-07 Actb, Dnm1, Crmp2, Ezr, Mapk1
Reactome:R-MMU-399956 Pathways CRMPs in Sema3A signaling 4 25.0 8.09E-08 Crmp1, Crmp2, Crmp3, Crmp4
Reactome:R-MMU-5663213 Pathways RHO GTPases Activate WASPs and WAVEs 4 12.5 1.55E-06 Actb, Arpc2, Arpc5, Mapk1
GO:0021762 Biological Process substantia nigra development 5 13.2 5.31E-08 Actb, Ckb, Cnp, Mbp, Ywhae
GO:0042470 Cellular Component melanosome 5 4.8 8.92E-06 Atp6v1b2, Cnp, Erp29, Hsp90b1, Ywhae
GO:0060052 Biological Process neurofilament cytoskeleton organization 3 30.0 2.13E-06 Nefl, Nefm, Sod1

% Associated Genes indicates the percent of the genes defining a given GO term that were listed (as accessions) in the ClueGO spot list. See Supplementary Tables S5 for more details and subnetworks.