Hippocampal BAG3, NBR1, NDP52, p62 and tau gene expression in WT (open bars) and in Nrf2 (−/−) mice (black bars) at 4 (A), 8 (B) and 12 (C) months. Relative mRNA level of each gene is compared with that of WT mice. Age-dependent changes in gene expression were analyzed in 12 month old mice relative to 4 month old WT mice (D). N=5–6 in each group, mean ± SEM, (*p<0.05, #p < 0.01, ^p < 0.001).