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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Neurobiol Aging. 2017 Dec 9;63:128–139. doi: 10.1016/j.neurobiolaging.2017.12.001

Figure 4. The levels of tau phosphorylated at T231 increase in the hippocampus of Nrf2 (−/−) mice.

Figure 4

Hippocampal tissue was collected from 4 (A, B), 8 (C, D) and 12 (E, F) month old WT and Nrf2(−/−) mice and immunoblotted for tau phosphorylated at T231 (AT180), S262 (12E8) or S398/404 (PHF1), or total tau. Representative immunoblots are shown in (A, C, E) and quantitated data in (B, D, F). Data were normalized to actin levels and quantitated as a function of WT levels at each age. At 8 and 12 months, total tau and pT231 tau levels were significantly higher in in the Nrf2(−/−) (black bars) compared to the WT mice (open bars). N=5–6 in each group, mean ± SEM, (*p<0.05, #p < 0.01, ^p < 0.001).