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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Trends Biochem Sci. 2017 Dec 14;43(2):95–107. doi: 10.1016/j.tibs.2017.11.010

Figure 1. Remodeling of CRL3BTB complexes mediated by CAND1 and CSN.

Figure 1

Upon substrate-induced neddylation, CRL3s are activated to ubiquitylate a specific substrate (CSN cycle). Once substrate is consumed, CSN-mediated cullin deneddylation allows binding of CAND1 (CAND1 cycle). The protein exchange factor activity of CAND1 causes displacement of the BTB protein. The released CRL3 core complex can then reassemble with another BTB protein presumably driven by cognate substrate.