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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2017 Nov 17;114:175–184. doi: 10.1016/j.yjmcc.2017.11.011

Figure 6. Ex vivo mouse working hearts at human-like heart rate preserve Frank-Starling response.

Figure 6

In comparison with 480 bpm controls, LV stroke volume at preload from 5 to 20 mmHg demonstrates a preserved Frank-Starling response at heart rate of 120–130 bpm (A). Although LV EDPVR was higher at the slower heart rate (Fig. 5B), LVPmin showed less increase at heart rate of 120–130 bpm when preload was increased (B). The human-like heart rate increased LVPmax (C) and systolic velocity (D) but not diastolic velocity (E). N = 6 hearts. Values are presented as mean ± SE. *P<0.05 vs. 480 bpm control in Student’s t test.