. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: J Mol Cell Cardiol. 2017 Nov 17;114:175–184. doi: 10.1016/j.yjmcc.2017.11.011

Table 3.

Improved contractile functions of mouse working heart at human-like heart rate

Heart Rate (bpm)	LVP max (mmHg)	LVP min (mmHg)	Stroke Volume (mL/mg)	+dP/dt max (mmHg/s)	−dP/dt max (mmHg/s)	LVEDV (μL)	LVESV (μL)
480	66.76±0.86	2.91±0.31	0.102±0.005	2869.07±139.04	−2624.95±94.29	30.26±3.14	19.87±2.54
128.6±14.8^*	78.88±2.49^*	1.93±0.35	0.220±0.013^*	3448.76±177.78^*	2510.14±118.44	41.23±4.57 (P=0.091)	23.93±2.75

At 5 mmHg preload and 55 mmHg afterload, mouse working hearts at human-like heart rate of 120–130 bpm in the presence of 300 μM lidocaine showed increased systolic function and stroke volume with increased diastolic filling in comparison to that at 480 bpm without lidocaine. N = 4 to 5 hearts.

Values are presented as Mean ± SE.

P<0.05 vs. 480 bpm control in Student’s t test.