. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: J Mol Cell Cardiol. 2017 Nov 17;114:175–184. doi: 10.1016/j.yjmcc.2017.11.011

Table 4.

Left ventricular systolic and diastolic time parameters (ms)

Heart Rate (bpm)	T P50	T PT	T R50	T R75	Ejection Time (ET)	Rapid ET	Reduced ET
480	21.87±0.63	41±0.41	42.62±0.82	50.75±1.05	47.75±1.43	10±1.22	37.75±0.25
128.6±14.8	26±0.96^*	51.4±2.48^*	50.3±3.10 (P=0.07)	60±3.36 (P=0.051)	69.4±2.09^*	20.2±3.65^*	49.2±3.06^*

The time parameters of ex vivo mouse working hearts under 5 mmHg preload and 55 mmHg afterload showed elongated left ventricular systolic time (total and 50% time to peak pressure, TPT and TP50) and diastolic time (time for 50% and 75% relaxation, TR50 and TR75) at human-like heart rate of 120–130 bpm in the presence of 300 μM lidocaine as compared with that at 480 bpm without lidocaine. N = 4 to 5 hearts.

Values are presented as Mean ± SE.

P<0.05 vs. 480 bpm control in Student’s t test.