Table 4.
Uni- and multivariate Cox regression analyses of FTO rs9939609 polymorphism in Unprovoked VTE patients
| All patients | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
||||||||||
| Univariate |
P |
Multivariate |
P* |
Univariate |
P |
Multivariate |
P* |
Univariate |
P |
Multivariate |
P* |
|
|
|
|
|
|
|
|
|||||||
| Genotypes | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||||
| rs9939609 | ||||||||||||
| TT | Reference | Reference | Reference | Reference | Reference | Reference | ||||||
| AT | 1.03 (0.63–1.70) | 0.900 | 0.85 (0.51–1.43) | 0.542 | 1.03 (0.50–2.12) | 0.939 | 0.92 (0.44–1.94) | 0.832 | 1.12 (0.56–2.32) | 0.740 | 0.90 (0.43–1.88) | 0.784 |
| AA | 1.24 (0.67–2.32) | 0.495 | 1.22 (0.65–2.27) | 0.541 | 1.97 (0.87–4.48) | 0.103 | 1.99 (0.88–4.53) | 0.101 | 0.67 (0.24–1.87) | 0.447 | 0.65 (0.23–1.82) | 0.412 |
| TT & AT | Reference | Reference | Reference | Reference | Reference | Reference | ||||||
| AA | 1.22 (0.70–2.11) | 0.478 | 1.33 (0.76–2.32) | 0.311 | 1.94 (0.98–3.86) | 0.059 | 2.09 (1.04–4.21) | 0.046 | 0.63 (0.25–1.61) | 0.333 | 0.69 (0.27–1.78) | 0.440 |
P* Adjusted for BMI, mild and severe thrombophilia, and family history of VTE.