Table 1.
The M. tuberculosis cytochrome P450 enzymes for which sufficient evidence is available to initiate a discussion of their potential as drug targets.
| Gene number | P450 number | Crystal structure | Substrate |
|---|---|---|---|
| Rv0764c | CYP51B1 | (11) | Lanosterol |
| Rv2276 | CYP121A1 | (12, 13) | Cyclodityrosine (cYY) |
| Rv2266 | CYP124A1 | (14) | Dimethyl chain termini: e.g., phytanic acid, farnesol |
| Rv3545c | CYP125A1 | (15, 16) | Cholesterol Cholest-4-en-3-one |
| Rv0778 | CYP126A1 | (17) | Unknown |
| Rv2268c | CYP128A1* | Menaquinone MK9(H2) | |
| Rv1256c | CYP130A1 | (18) | Unknown |
| Rv3518c | CYP142A1 | (19, 20) | Cholesterol Cholest-4-en-3-one |
| Rv1777 | CYP144A1 | (21) | Unknown |
*
No crystal structure is available for this enzyme