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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Ann N Y Acad Sci. 2018 Jan 28;1413(1):92–103. doi: 10.1111/nyas.13561

Table 4.

An overview of the commonalities and differences between the several specific IgG4-mediated autoimmune diseases.

Commonalities

  • Predominating IgG4 autoantibodies

  • The antigens (so far) do not include essential ion channels or multisubunit receptors

  • The antigens are part of important protein–protein interactions that maintain cell–cell contact, stabilize ion channels, or mediate proteolysis.

  • The antigens are highly N-glycosylated

  • The pathogenic mechanism is blocking of protein–protein interaction and function

  • Strong HLA class II associations

  • Good response to rituximab treatment

Differences

  • The antigens recognized

  • Main immunogenic regions reside in different types of protein domains

  • Some require proper antigen glycosylation for autoantibody–antigen binding

  • Type of HLA class II genes associated

  • Type of VDJ gene usage