DCs were primed with PPM, M278 or PPP before co-culturing with T cells from naïve and C. muridarum vaccinated mice. For intracellular IFN-γ secretion, cells were stained with CD3-APC-Cy7 and CD4-PerCP-Cy5.5 followed by staining with IFN-γ-APC. Analyses were performed by gating on CD3+ IFN-γ secreting cells for naïve ((A, B, C) and vaccinated co-cultures (D, E, F) and also for CD4+ IFN-γ secreting cells from naïve (G, H, I) and vaccinated (J, K, L) mice.