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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Toxicology. 2017 Dec 21;395:1–8. doi: 10.1016/j.tox.2017.12.007

Figure 1. The National Research Council’s (NRC) Low-Dose Linearity Hypothesis.

Figure 1

As published in a report in 2009 call “Science and Decisions: Advancing Risk Assessment,” the NRC suggest that, in considering population-level genetic variability, the low-dose region of non-cancer dose-response relationships will linearize. As such, the NRC recommends that there are no safe exposures of chemicals that induced adverse, non-cancer endpoints.