Table 3. Enriched pathways of the 5 miRNAs from the 3 miRNA ratios to differentiate adenoma and CRC patients from healthy control group.
| Database | Pathways | ID | Genes | Targets | miRNAs | Empirical P value |
|---|---|---|---|---|---|---|
| KEGG | Calcium signaling pathway | 4020 | 177 | 9 | 3 | 1.64E-04 |
| PATHWAY INTERACTION DATABASE | C-myb transcription factor network | 200154 | 81 | 5 | 5 | 1.50E-02 |
| REACTOME | VIF-mediated degradation of APOBEC3G | REACT 9453 | 54 | 4 | 3 | 1.77E-02 |
| REACTOME | Metabolism of amino acids and derivatives | REACT 13 | 174 | 6 | 4 | 2.43E-02 |
| REACTOME | APC C CDH1 mediated degradation of CDC20 and other APC C CDH1 targeted proteins in late mitosis early G1 | REACT 6761 | 69 | 4 | 3 | 2.93E-02 |
| GO MOLECULAR FUNCTION TIER2 | Protein binding transcription factor activity | GO: 0000988 | 369 | 12 | 5 | 3.38E-02 |
| KEGG | Glycerolipid metabolism | 561 | 49 | 2 | 2 | 3.54E-02 |
| KEGG | Lysosome | 4142 | 121 | 4 | 3 | 3.55E-02 |
| REACTOME | Integration of energy metabolism | REACT 1505 | 125 | 5 | 3 | 3.94E-02 |
| KEGG | Amino sugar and nucleotide sugar metabolism | 520 | 47 | 3 | 2 | 4.22E-02 |
| REACTOME | Destabilization of MRNA by AUF1 (HNRNP D0) | REACT 25325 | 54 | 4 | 2 | 4.30E-02 |
| KEGG | Oocyte meiosis | 4114 | 112 | 4 | 3 | 4.39E-02 |
| KEGG | Tyrosine metabolism | 350 | 41 | 2 | 2 | 4.56E-02 |
| REACTOME | Biological oxidations | REACT 13433 | 139 | 4 | 4 | 4.59E-02 |
Empirical P values were compared with 1,000 random selections.
Analyzed with miR-17-5p, miR-135b, miR-92a-3p, miR-451 and miR-491-5p
Metabolism-related pathways are in bold font.