Table 4. Enriched pathways of the 7 miRNAs of the 5 miRNA ratios to differentiate patients with CRC from adenoma and healthy control groups.
| Database | Pathways | ID | Genes | Targets | miRNAs | Empirical P value |
|---|---|---|---|---|---|---|
| KEGG | Protein processing in endoplasmic reticulum | 4141 | 166 | 8 | 6 | 6.23E-03 |
| KEGG | Chemokine signaling pathway | 4062 | 189 | 8 | 6 | 7.23E-03 |
| REACTOME | Chemokine receptors bind chemokines | REACT 15344 | 54 | 4 | 3 | 8.36E-03 |
| PATHWAY INTERACTION DATABASE | ATF-2 Transcription factor network | 200136 | 58 | 5 | 6 | 8.84E-03 |
| PATHWAY INTERACTION DATABASE | Direct P53 effectors | 200120 | 137 | 6 | 6 | 9.07E-03 |
| BIOCARTA | Biocarta NKT pathway | 28 | 4 | 2 | 1.02E-02 | |
| REACTOME | GPCR ligand binding | REACT 21340 | 410 | 11 | 5 | 1.17E-02 |
| REACTOME | G alpha (I) signaling events | REACT 19231 | 200 | 6 | 4 | 1.53E-02 |
| KEGG | Dilated cardiomyopathy | 5414 | 90 | 4 | 7 | 1.70E-02 |
| KEGG | Olfactory transduction | 4740 | 388 | 1 | 2 | 1.72E-02 |
| REACTOME | Peptide ligand-binding receptors | REACT 14819 | 186 | 6 | 5 | 1.78E-02 |
| KEGG | Cytokine-cytokine receptor interaction | 4060 | 275 | 9 | 5 | 1.82E-02 |
| REACTOME | G alpha (S) signalling events | REACT 19327 | 125 | 5 | 5 | 1.97E-02 |
| REACTOME | Class A 1 (Rhodopsin-like receptors) | REACT 14828 | 305 | 8 | 5 | 2.11E-02 |
| REACTOME | Hemostasis | REACT 604 | 467 | 11 | 7 | 2.50E-02 |
| KEGG | Nucleotide excision repair | 3420 | 44 | 3 | 4 | 2.95E-02 |
| REACTOME | Endosomal sorting complex required for transport (ESCRT) | REACT 27258 | 28 | 4 | 3 | 3.04E-02 |
| PATHWAY INTERACTION DATABASE | P75(NTR)-mediated signaling | 200123 | 67 | 5 | 5 | 3.24E-02 |
| REACTOME | G ALPHA (Z) signaling events | REACT 19333 | 45 | 3 | 4 | 3.52E-02 |
| REACTOME | Cell cycle checkpoints | REACT 1538 | 117 | 5 | 6 | 3.59E-02 |
| REACTOME | Transcription-coupled NER (TC-NER) | REACT 1628 | 44 | 3 | 4 | 3.70E-02 |
| REACTOME | Nucleotide excision repair | REACT 1826 | 49 | 3 | 4 | 4.03E-02 |
| REACTOME | DNA repair | REACT 216 | 108 | 4 | 4 | 4.24E-02 |
| REACTOME | PLC-Gamma1 signaling | REACT 12079 | 34 | 2 | 3 | 4.43E-02 |
| KEGG | Neurotrophin signaling pathway | 4722 | 127 | 5 | 5 | 4.89E-02 |
| REACTOME | APC C CDC20 mediated degradation of mitotic proteins | REACT 6781 | 69 | 4 | 6 | 4.94E-02 |
Empirical P values were compared with 1,000 random selections.
Analyzed with let-7b, miR-367-3p, miR-130a-3p, miR-409-3p, miR-148-3p, miR-27b, and miR-21-5p.
Immune-related pathways are in bold font.