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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Cortex. 2017 Nov 8;99:69–77. doi: 10.1016/j.cortex.2017.10.015

Figure 3. Tangle/pre-tangle-bearing von Economo Neurons (VENs) in anterior cingulate cortex of postmortem cases with Alzheimer disease.

Figure 3

Very sparse, infrequent VENs are demonstrated at 40x magnification in vertical orientation and are characterized based on their slender morphology and bipolar dendritic architecture. In some cases, VENs appeared dysmorphic. Tangle/pre-tangle-bearing VENs are visualized with PHF-1 (A & B), PAM (C), and Alz50 (D). Scale bar at 5 μm.