Table 2.

Regions of decreased gray matter density in single ventricle heart disease and controls.

Brain region	SVHD (mean ± SD) n = 18; unit = mm3/voxel	Control (mean ± SD) n = 31; unit = mm3/voxel	Cluster Size (voxels)	P value
R Thalamus	2.16 ± 0.19	2.42 ± 0.12	12939	< 0.001
L Thalamus	2.41 ± 0.19	2.72 ± 0.12	13922	< 0.001
R Putamen	1.92 ± 0.14	2.08 ± 0.11	6016	< 0.001
L Putamen	1.61 ± 0.12	1.75 ± 0.10	5285	< 0.001
R Caudate Nucleus	2.24 ± 0.20	2.50 ± 0.13	10073	< 0.001
L Caudate Nucleus	2.32 ± 0.17	2.55 ± 0.11	9612	< 0.001
R Insula	2.48 ± 0.13	2.62 ± 0.10	1999	< 0.001
L Insula	2.17 ± 0.16	2.31 ± 0.11	1400	< 0.001
R Precentral Gyrus	1.79 ± 0.11	1.92 ± 0.06	3005	< 0.001
L Precentral Gyrus	1.28 ± 0.09	1.41 ± 0.08	1214	< 0.001
R Postcentral Gyrus	1.96 ± 0.13	2.12 ± 0.08	7178	< 0.001
L Postcentral Gyrus	1.35 ± 0.09	1.45 ± 0.06	1026	< 0.001
R Prefrontal Cortices	0.49 ± 0.02	0.36 ± 0.05	25	0.001
L Prefrontal Cortices	0.37 ± 0.02	0.34 ± 0.04	19	0.001
R Superior Temporal Gyrus	1.93 ± 0.13	2.04 ± 0.11	101	0.001
L Superior Temporal Gyrus	2.25 ± 0.09	2.36 ± 0.08	1166	< 0.001
R Middle Temporal Gyrus	2.18 ± 0.16	2.31 ± 0.09	393	< 0.001
L Middle Temporal Gyrus	1.96 ± 0.13	2.08 ± 0.08	3001	< 0.001
R Inferior Temporal Gyrus	2.16 ± 0.17	2.29 ± 0.10	255	< 0.001
L Inferior Temporal Gyrus	2.19 ± 0.10	2.30 ± 0.07	168	< 0.001
R Parahippocampal Gyrus	1.75 ± 0.11	1.86 ± 0.10	14	0.001
L Parahippocampal Gyrus	1.83 ± 0.07	1.92 ± 0.06	62	< 0.001
R Cerebellum	1.96 ± 0.15	2.09 ± 0.10	2089	< 0.001
L Cerebellum	1.65 ± 0.13	1.77 ± 0.09	819	< 0.001
L Middle Occipital Gyrus	1.54 ± 0.16	1.66 ± 0.08	192	0.001
L Inferior Occipital Gyrus	1.43 ± 0.15	1.55 ± 0.08	1328	< 0.001

SVHD, Single ventricle heart disease; SD, Standard Deviation; L, Left; R, Right.