Table 4.
Change in HbA1c and weight from baseline and proportion achieving combined glycemic and weight loss targets for patients initiating therapy with either exenatide QW or basal insulin: propensity matched patients
| 6 months | 12–24 months | |||||
|---|---|---|---|---|---|---|
| Exenatide QW | Basal insulin | p | Exenatide QW | Basal insulin | p | |
| HbA1c change from baseline | ||||||
| n | 206 | 206 | 111 | 111 | ||
| Female [n (%)] | 81 (39.3%) | 91 (44.2%) | 39 (35.1%) | 39 (35.1%) | ||
| Baseline age [mean years, (sd)] | 57.7 (11.1) | 59.5 (11.8) | 57.9 (10) | 58.5 (11) | ||
| Baseline HbA1c % [mean, (sd)] | 9.51 (1.58) | 10.07 (1.83) | 9.51 (1.71) | 9.83 (1.62) | ||
| Baseline HbA1c mmol/mol [mean, (sd)] | 80.2 (17.2) | 86.3 (19.9) | 80.2 (18.6) | 83.7 (17.7) | ||
| Mean (sd) absolute HbA1c % change | − 1.33 (1.38) | − 1.24 (2.01) | − 1.19 (1.73) | − 1.17 (1.91) | ||
| Mean (sd) absolute HbA1c mmol/mol change | − 14.5 (15.0) | − 13.5 (21.9) | − 13.0 (18.9) | − 12.8 (20.8) | ||
| Mean HbA1c % difference (95% CI) | − 0.09 (− 0.43 to 0.24) | 0.45 | − 0.02 (− 0.51 to 0.46) | 0.899 | ||
| Mean HbA1c mmol/mol difference (95% CI) | − 1.00 (− 4.7 to 2.5) | 0.45 | − 0.2 (− 5.6 to 5.0) | 0.899 | ||
| Weight change from baseline | ||||||
| n | 201 | 201 | 100 | 100 | ||
| Female [n (%)] | 70 (34.8%) | 69 (34.3%) | 37 (37.0%) | 48 (48.0%) | ||
| Baseline age [mean years, (sd)] | 56.9 (10.5) | 57.1 (12.4) | 58.6 (10.2) | 59.4 (11.2) | ||
| Baseline weight [mean kg, (sd)] | 110.67 (19.9) | 107.99 (22.16) | 108.27 (19.62) | 103.09 (20.57) | ||
| Mean (sd) absolute change (kg) | − 3.70 (4.42) | 1.20 (5.72) | − 3.24 (5.32) | 2.48 (6.3) | ||
| Mean difference (kg, 95% CI) | − 4.9 (− 5.9 to − 3.9) | < 0.001 | − 5.73 (− 7.36 to − 4.1) | < 0.001 | ||
| Patients reaching target | ||||||
| n | 161 | 161 | 88 | 88 | ||
| Female [n (%)] | 56 (34.8%) | 53 (32.9%) | 32 (36.4%) | 36 (40.9%) | ||
| Baseline age [mean years, (sd)] | 57.2 (10.2) | 57.4 (13.1) | 57.7 (10.9) | 56.3 (12.3) | ||
| Baseline HbA1c % [mean, (sd)] | 9.43 (1.53) | 9.29 (1.83) | 9.53 (1.64) | 9.53 (1.71) | ||
| Baseline HbA1c mmol/mol [mean, (sd)] | 79.3 (16.7) | 77.8 (19.9) | 80.4 (17.9) | 80.4 (18.6) | ||
| Baseline weight [mean, (sd)] | 110.72 (19.93) | 106.05 (20.17) | 107.13 (18.83) | 103.51 (18.06) | ||
| HbA1c ≤ 7.0% (53 mmol/mol) and any weight loss | 36 (22.4%) | 16 (9.9%) | 0.002 | 16 (18.2%) | 7 (8.0%) | 0.044 |
| HbA1c ≤ 7.0% (53 mmol/mol) and weight loss ≥ 5% | 19 (11.8%) | 6 (3.7%) | 0.007 | 7 (8.0%) | 0 (0%) | 0.007 |