Table 4.
OCT qualitative analysis in the entire stent.
| Variable |
First generation (n = 1036) |
p |
Second generation (n = 641) |
p |
p* |
p** |
||
|---|---|---|---|---|---|---|---|---|
| ≤ 1 year (n = 309) | > 1 year (n = 727) | ≤ 1 year (n = 496) | > 1 year (n = 145) | |||||
| Homogeneous | 132 (42.7) | 515 (70.8) | < 0.01 | 155 (31.2) | 32 (22.1) | 0.04 | < 0.01 | < 0.01 |
| Heterogeneous | 117 (37.9) | 161 (22.2) | < 0.01 | 283 (57.1) | 85 (58.6) | 0.70 | < 0.01 | < 0.01 |
| Layered | 9 (7.7) | 69 (42.9) | 40 (14.1) | 26 (31.7) | ||||
| Patchy | 87 (75.0) | 74 (46.0) | 211 (7.5) | 5 0(58.8) | ||||
| Speckled | 21 (18.1) | 18 (11.2) | 32 (11.3) | 9 (10.6) | ||||
| Neo-atherosclerosis | 60 (19.4) | 51 (7.0) | < 0.01 | 58(11.7) | 28(19.3) | 0.01 | < 0.01 | < 0.01 |
| Lipids | 59 (19.1) | 34 (4.7) | < 0.01 | 49 (9.9) | 26 (17.9) | 0.01 | < 0.01 | < 0.01 |
| Calcium | 20 (6.5) | 10 (1.4) | < 0.01 | 7 (1.4) | 4 (2.8) | 0.28 | < 0.01 | 0.27 |
| TCFA | 3 (1.0) | 7 (1.0) | 0.99 | 2 (0.4) | 0 (0.0) | 0.98 | 0.32 | 0.61 |
| Macrophages | 3 (1.0) | 6 (0.8) | 0.73 | 3 (0.6) | 0 (0.0) | 0.35 | 0.56 | 0.60 |
| Microvessels | 8 (2.6) | 2 (0.3) | < 0.01 | 1 (0.2) | 1 (0.7) | 0.35 | < 0.01 | 0.44 |
| PSLIA | 48 (15.5) | 65 (8.9) | < 0.01 | 57 (11.5) | 39 (26.9) | < 0.01 | 0.11 | < 0.01 |
| Overlapping CSs | 31 (10.0) | 65 (8.9) | 0.56 | 36 (7.3) | 11 (7.6) | 0.86 | 0.19 | 0.75 |
| Malapposed struts | 0 (0.0) | 12 (1.7) | 0.08 | 4 (0.8) | 1 (0.7) | 0.89 | 0.11 | 0.65 |
| Uncovered struts | 3 (1.0) | 22 (3.0) | 0.04 | 15 (3.0) | 2 (1.4) | 0.39 | 0.08 | 0.41 |
Categorical variables are expressed as number (%). CSs: cross-sections; OCT: optical coherence tomography; PSLIA: peri-strut low intensity area. p: comparison within each DES generation; p*: comparison of early ISR between generations; p**: comparison of late ISR between generations.