Table 1.
Mortality rates (per 100 person-years) and mortality rate ratios (MRR) for after-campaign vs before-campaign children enrolled in seven randomized controlled trials (RCTs), presented by campaign type.
| Variable | Rate per 100 person-years (deaths/person-years) |
MRR#1 | MRR#2 | MRR#3 | |
|---|---|---|---|---|---|
| After-campaign | Before-campaign | ||||
| Campaign-OPV-only | 2.04 (316/15,462) | 5.05 (928/18,360) | 0.81 (0.70–0.93) | 0.83 (0.71–0.97) | 0.81 (0.68–0.95) |
| Campaign-OPV + VAS | 1.51 (117/7,761) | 4.32 (1127/26,061) | 0.99 (0.78–1.24) | 0.95 (0.73–1.24) | 1.10 (0.82–1.48) |
| Campaign-VAS-only | 1.49 (176/11824) | 4.86 (1068/21998) | 0.92 (0.74–1.15) | 1.06 (0.83–1.34) | 1.04 (0.80–1.35) |
| Campaign-H1N1 | 3.06 (12/393) | 3.69 (1232/33429) | 1.14 (0.64–2.04) | 1.65 (0.91–2.99) | 1.86 (1.02–3.42) |
| Campaign-MV | 2.03 (18/888) | 3.72 (1226/32934) | 1.10 (0.68–1.77) | 1.16 (0.70–1.93) | 1.24 (0.74–2.09) |
MRR#1: adjusting for age (underlying time).
MRR#2: adjusting for age (underlying time), year⋆age group, strata (LBW, season).
MRR#3: Full multivariable model: adjusting for age (underlying time), OPV, OPV + VAS, VAS, H1N1, MV, year⋆age group, strata (LBW, season).
There were 1,244 deaths in the seven RCTs. Since “before-campaign” children were generally younger than the “after-campaign” children the MRR cannot be deduced directly from the mortality rates.