FIGURE 2.

The distribution and the spectrum of TP53 mutations. The distribution and spectrum of TP53 missense (A,B) and deleterious (C,D) mutations in hepatocellular carcinoma (A,C) and in non-liver TCGA datasets (B,D). Diagrams represent the protein domains of p53 encoded by the TP53 gene. The presence of a mutation is shown on the x axis (lollipop), and the frequency of mutations is shown on the y axis. Missense mutations are presented as green circles, deleterious mutations (i.e., nonsense, frameshift, splice-site and in-frame) are depicted in black and brown circles. Plots were generated using cBioPortal tools (http://www.cBioPortal.org) and curated manually.