Table 1.
A summary of the main studies assessing the frequency of post-traumatic hypopituitarism.
| Study | Patient number | Male/female | Median age at traumatic brain injury (TBI) | TBI severity | Timing of test post TBI | LH/FSH def. | Growth hormone def. | TSH def. | ACTH def. | Diabetes insipidus |
|---|---|---|---|---|---|---|---|---|---|---|
| Personnier et al. (9) | 87 | 60/27 | 5.9 (0.2–14.4) | Severe | 6–18 months | – | 31% | 2.3% | 1.1% | – |
| Baxter et al. (10) | 19 | 19/0 | 26.7 (26.1–30.9) | Moderate–severe | 2–48 months | 5.3% | 15.8% | 0% | 10.5% | 0% |
| Hannon et al. (11) | 32 | – | – | Moderate–severe | 6–24 months | 3.1% | 18.8% | 0% | 18.8% | – |
| Hannon et al. (11) | 100 | 85/15 | 33 (18–75) | Moderate–severe | 1–22 days | – | – | – | 78% | 51% |
| Kozlowski Moreau et al. (12) | 55 | 46/9 | 36.1 | Mild–severe | At least 12 months | – | 40% | 21.8% | 27.3% | – |
| Schneider et al. (13) | 78 | 52/26 | 36.0 | Mild–severe | 3 months | 32.4% | 9.1% | 7.8% | 19.5% | – |
| Schneider et al. (13) | 70 | 47/23 | 35.7 | Mild–severe | 12 months | 28.6% | 14.3% | 4.3% | 12.9% | – |
| Agha et al. (14) | 102 | 85/17 | 28 (15–65) | Moderate–severe | 6–36 months | 11.8% | 10.7% | 1.0% | 12.7% | – |
| Tanriverdi et al. (15) | 52 | 43/9 | 35.9 (17–65) | Mild–severe | 12 months | 41.6% | 20.4% | 5.8% | 9.8% | – |
| Aimaretti et al. (16) | 70 | 50/20 | 39.31 | Mild–severe | 3 months | 17.1% | 38.5% | 5.7% | 8.5% | 4.2% |
| Aimaretti et al. (16) | 70 | 50/20 | 39.31 | Mild–severe | 12 months | 11.4% | 38.6% | 5.7% | 7.1% | 2.8% |
| Agha et al. (17) | 102 | 85/17 | 28 (15–65) | Moderate–severe | 1–24 days | – | – | – | – | 21.6% |
| Agha et al. (17) | 102 | 85/17 | 28 (15–65) | Moderate–severe | 6–36 months | – | – | – | – | 6.9% |