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. 2018 Jan 15;10(1):16–39.

Figure 4.

Figure 4

Preeclamptic placentas were hypermethylated with higher expression of 5mC, DNMT1 and DNMT3b, and lower expression of DNMT3a compared with normal pregnant placentas. A, B. Immunohistochemistry and ELISA showed increased 5mC levels in PE group compared to NP group. C-E. Immunohistochemistry, western blot and qRT-PCR revealed higher DNMT1 in PE group than NP group. F-H. Immunohistochemistry showed no significance of DNMT3a, while western blot and qRT-PCR depicted lower DNMT3a in PE group than NP group. I-K. Immunohistochemistry showed no significance of DNMT3b, while western blot and qRT-PCR depicted higher DNMT3b in PE group than NP group. Data were shown as Mean ± SD. *P<0.05, **P<0.01, ***P<0.001. NP refers to normal pregnancy, PE refers to preeclampsia.