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Hypoxic trophoblasts were hypermethylated with increased 5mC, DNMT1 and DNMT3b, and decreased DNMT3a compared to normoxic trophoblasts. A. Increased 5mC in hypoxic HTR8 and JEG3 cells. B. Increased DNMT1 in hypoxic HTR8 and JEG3 cells. C. Decreased DNMT3a in hypoxic HTR8 and JEG3 cells. D. Decreased DNMT3b mRNA levels from 24 h to 72 h and increased DNMT3b mRNA levels in 96 h in hypoxic HTR8 and JEG3 cells. Data were shown as Mean ± SD. *P<0.05, **P<0.01, ***P<0.001.
