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. 2018 Jan 15;10(1):16–39.

Figure 11.

Figure 11

Downregulation of IGF-1 didn’t change genomic DNA hydroxymethylation. A. IGF-1 was downregulated by IGF-1-siRNA. B. Downregulation of IGF-1 didn’t change DNMT1 expression. C. Downregulation of IGF-1 didn’t change DNMT3a expression. D. Downregulation of IGF-1 didn’t change DNMT3b expression. E. Downregulation of IGF-1 didn’t change 5mC levels. F. Downregulation of IGF-1 didn’t alter TET1 expression. G. Downregulation of IGF-1 didn’t alter TET2 expression. H. Downregulation of IGF-1 didn’t alter TET3 expression. I. Downregulation of IGF-1 didn’t alter 5hmC levels. Data were shown as Mean ± SD. *P<0.05, **P<0.01, ***P<0.001. NC refers to negative control.