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. 2018 Feb 2;8:14. doi: 10.3389/fcimb.2018.00014

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Copyright © 2018 Sinclair and Shetty.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Delta PSI and gene-level differential expression. The absolute values of PSI for isoforms assigned to a specific gene were plotted against the gene-level differential expression in A. phagocytophilum-infected vs. uninfected ATRA-differentiated HL-60 cells. Thirteen genes had ΔPSI greater than 7.5%, but only eight had gene-level differential expression greater or less than 2-fold. Of the three genes with the greatest ΔPSI, none had gene-level differential expression changes greater or less than 2-fold, but at least one isoform for each of these was expressed at 2-fold greater or 2-fold lower levels than in uninfected cells.