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. 2018 Feb 2;9:156. doi: 10.3389/fimmu.2018.00156

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Copyright © 2018 Seliga, Lee, Fernandes, Zuluaga-Ramirez, Didukh, Persidsky, Potula, Gallucci and Sriram.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bradykinins (BKs) suppress pro-inflammatory cytokine production in murine bone-marrow-derived dendritic cells (BMDCs). (A,B) Flt3L grown BMDCs from B6 or Sle mice were stimulated with CpG-A or R848 overnight and then stimulated with BK. Cell supernatants were collected at 24 h of total stimulation to analyze the cytokines, IL-6 (A) and IL12p70 (B) by ELISA. (C,D) GMCSF-grown BMDCs from B6 mice were stimulated with CpG-B or R848 overnight and then stimulated with BK and cell supernatants were collected at 24 h of total stimulation to analyze the cytokines, IL-6 (C) and IL12p70 (D) by ELISA. Percent change in cytokine production was calculated from no BK treatment for each experiment. Bar graphs are mean + SE of at three independent experiments (*p < 0.05; **p < 0.01).